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1.D.177.  The Multivalent Superstructure Cation Transporter (MSCT) Family

A synthetic membrane transporter operates in vesicles by a relay mechanism (McNally et al. 2008). The transporter is a phosphatidylcholine derivative with a urea group appended to the end of its sn-2 acyl chain. The urea can bind a chloride ion at the membrane surface via hydrogen bonds and then relay it through the bilayer interior to an acceptor molecule located in the opposite membrane leaflet. Three phosphatidylcholine derivatives were studied, and transport rates increased with transporter affinity for chloride. The results of various control studies suggested an anion countertransport process using a relay mechanism and a kinetically active aggregate of two or four transporter molecules. Transport is inhibited if the transporter resides in only one leaflet of the membrane, if the bilayer is too thick, and if the counteranion is a sulfate dianion. The expected favorable formulation properties of these amphiphilic compounds should facilitate efforts to transform them into tools for biomedical research and perhaps as therapeutic agents (McNally et al. 2008).


References associated with 2.B.64 family:

McNally, B.A., E.J. O'Neil, A. Nguyen, and B.D. Smith. (2008). Membrane transporters for anions that use a relay mechanism. J. Am. Chem. Soc. 130: 17274-17275. 19035637