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2.B.67.  The Light-driven K+ Carrier (MC2) Family 

The light-driven motor molecule, MC2, forms a selective K+ transporter through a single molecular transmembrane mechanism, and the light-driven rotary motion significantly accelerates ion transport, which endows the irradiated motor molecule with cytotoxicity and cancer cell selectivity (Yang et al. 2022). It consists of a central rotor and stator as well as two distal K+ binding domains.  Mechanistic studies revealed that the rotary motion of MC2 promotes K+ efflux, generates reactive oxygen species and activates caspase-3-dependent apoptosis in cancer cells. A single molecule vertically inserts and spans the lipid membrane to form a stable and selective K+ channel. Then, the rotary motion of the motor provides actuation energy to accelerate ion transport in the channel and realize light-gated function. These unique features can play a role in regulating intracellular K+ concentrations, presenting a new drug discovery strategy for the treatment of cancer and other diseases (Yang et al. 2022).

References associated with 2.B.67 family:

Yang, H., J. Yi, S. Pang, K. Ye, Z. Ye, Q. Duan, Z. Yan, C. Lian, Y. Yang, L. Zhu, D.H. Qu, and C. Bao. (2022). A Light-Driven Molecular Machine Controls K Channel Transport and Induces Cancer Cell Apoptosis. Angew Chem Int Ed Engl e202204605. [Epub: Ahead of Print] 35442566