3.E.1.5.1
Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein of 626 aas; light-activated enzyme, RhCG, Gc1 or Cyc1Op. The central bacteriorhodopsin domain with 7 TMSs is linked via an additional TMS to the C-terminal adenylate/guanylate cyclase catalytic domain. CyclOp enables precise and rapid optogenetic manipulation of cGMP levels in cells and
animals (Gao et al. 2015).
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| Accession Number: | AIC07007 |
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| Protein Name: | AIC07007.1 bacterio-rhodopsin/guanylyl cyclase 1 fusion protein [Blastocladiella emersonii] |
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| Length: | 627 |
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| Molecular Weight: | |
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| Species: | Blastocladiella emersonii [4808] |
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| Number of TMSs: | 7 |
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| Substrate |
hydron |
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1: MKDKDNNLRG ACSSCNCPEY CFSPTSTLCD DCKCSVTKHP IVEQPLSRNG SFRSSGASLL
61: PSPSSPNVKI TSTVGLRSRK SESQANVRGS MISNSNSGSR SNNSGGAGGG SGGSSSSKGG
121: SALANYQSAM SELWSWNMML STPSLKFLTV QFTTWIVLTT VGAIYTLFFH ERQAYNRGWA
181: DIWYGYGAFG FGLGLSFAYM GFTGARNPEK KALSLCLLGV NFISFMSYII IMLRLTPTIE
241: GTMANPVEPA RYLEWIATCP VLILLISEIT QYPHDPYKVI VNDYALCLAG FVGAISAQQP
301: WGDLAHFVSC LCFSYVVYSL WSCFTGAIDG ETQCNVEKSG LRWIRFSTIT TWSLFPITWF
361: SYTSGLISFT VAEAGFSMID IGAKVFLTLV LVNSTVEQAQ NQKVDAITAI AEELENQINN
421: CDAILQKMMP EGVLEQLKNG QATEAKEYES VTVFFSDITN FTVISSRTST KDMMATLNKL
481: WLEYDAIAKR WGVYKVETIG DAYLGVTGAP DVVPDHAERA CNFAVDIIEM IKSFKTITGE
541: SINIRIGLNS GPVTAGVLGD LNPHWCLVGD TVNTASRMES TSKAGHIHIS ESTYHFIKSK
601: FVTQPLDVME VKGKGKMQTY WVLGRK