3.E.1.7.3
Channelrhodopsin-2 (ChR2) of light-gated ion channel. A 6 Å projection map is available (Müller et al., 2011). Glutamate residue-97 lies in the outer pore where it interacts with a cation to facilitate dehydration. This residue is also the primary binding target of Gd3+ (Tanimoto et al., 2012). Cardiomyocytes expressing ChR2 upon optical stimulation depolarize, resulting from alterations of membrane voltage and intracellular calcium (Keshmiri Neghab et al. 2021).
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| Accession Number: | B4Y105 |
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| Protein Name: | Channelrhodopsin-2 |
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| Length: | 747 |
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| Molecular Weight: | 77829.00 |
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| Species: | Volvox carteri f. nagariensis [3068] |
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| Number of TMSs: | 7 |
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| Substrate |
ion |
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| Pfam: |
PF01036
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[1] “Channelrhodopsins of Volvox carteri Are Photochromic Proteins That Are Specifically Expressed in Somatic Cells under Control of Light, Temperature, and the Sex Inducer.” Kianianmomeni A. et.al. 19641026
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1: MDHPVARSLI GSSYTNLNNG SIVIPSDACF CMKWLKSKGS PVALKMANAL QWAAFALSVI
61: ILIYYAYATW RTTCGWEEVY VCCVELTKVV IEFFHEFDEP GMLYLANGNR VLWLRYGEWL
121: LTCPVILIHL SNLTGLKDDY NKRTMRLLVS DVGTIVWGAT AAMSTGYIKV IFFLLGCMYG
181: ANTFFHAAKV YIESYHTVPK GLCRQLVRAM AWLFFVSWGM FPVLFLLGPE GFGHLSVYGS
241: TIGHTIIDLL SKNCWGLLGH FLRLKIHEHI LLYGDIRKVQ KIRVAGEELE VETLMTEEAP
301: DTVKKSTAQY ANRESFLTMR DKLKEKGFEV RASLDNSGID AVINHNNNYN NALANAAAAV
361: GKPGMELSKL DHVAANAAGM GGIADHVATT SGAISPGRVI LAVPDISMVD YFREQFAQLP
421: VQYEVVPALG ADNAVQLVVQ AAGLGGCDFV LLHPEFLRDK SSTSLPARLR SIGQRVAAFG
481: WSPVGPVRDL IESAGLDGWL EGPSFGLGIS LPNLASLVLR MQHARKMAAM LGGMGGMLGS
541: NLMSGSGGVG LMGAGSPGGG GGAMGVGMTG MGMVGTNAMG RGAVGNSVAN ASMGGGSAGM
601: GMGMMGMVGA GVGGQQQMGA NGMGPTSFQL GSNPLYNTAP SPLSSQPGGD ASAAAAAAAA
661: AAATGAASNS MNAMQAGGSV RNSGILAGGL GSMMGPPGAP AAPTAAATAA PAVTMGAPGG
721: GGAAASEAEM LQQLMAEINR LKSELGE