TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
4.C.3.1.1









Peroxisomal Acyl-CoA thioesterase 5, Acot5 (2-4 putative TMSs) It has two domains: N-terminal bile acid-CoA:amino acid N-acetyl transferase domain and a C-terminal Acyl-CoA thioester hydrolase domain.

Eukaryota
Metazoa
Acot5 of Mus musculus (Q6Q2Z6)
4.C.3.1.2









Acyl-CoA thioesterase of 432 aas.

Bacteria
Firmicutes
Acyl-CoA thioesterase of Clostridioides difficile
4.C.3.1.3









Uncharacterized protein of 359 aas

Bacteria
Proteobacteria
UP of Paenalcaligenes hominis
4.C.3.1.4









Alpha/beta hydrolase of 325 aas

Bacteria
Actinobacteria
Hydrolase of Mycobacteroides abscessus
4.C.3.1.5









Uncharacterized protein of 264 aas

Archaea
Candidatus Thorarchaeota
UP of Candidatus Thorarchaeota archaeon
4.C.3.1.6









Uncharacterized protein of 449 aas

Eukaryota
Fungi
UP of Fusarium oxysporum
4.C.3.1.7









Esterase of 574 aas

Bacteria
Spirochaetes
Esterase of Leptospira biflexa
4.C.3.1.8









Acyl-CoA thioesterase  of 647 aas and 5 N-terminal TMSs

Bacteria
Actinobacteria
Thioesterase of Actinomycetospora cinnamomea
4.C.3.1.9









Alpha/beta hydrolase of 471 aa

Bacteria
Bacteroidetes
Hydrolase of Pontibacter lucknowensis
4.C.3.1.10









Uncharacterized protein of 774 aas and 1 N-terminal TMS

Bacteria
Balneolaeota
UP of Aliifodinibius sediminis
4.C.3.1.11









Alpha/beta hydrolase fold domain-containing protein of 308 aas

Bacteria
Verrucomicrobia
Hydrolase of Opitutaceae bacterium
4.C.3.1.12









Uncharacterized protein of 603 aas

Bacteria
Candidatus Aminicenantes
UP of Candidatus Aminicenantes bacterium (sediment metagenome)
4.C.3.1.13









Prolyl oligopeptidase family serine peptidase of 254 aas and 1 TMS.

Bacteria
Proteobacteria
Peptidase of Halomonas alkaliphila
4.C.3.1.14









Carboxymethylenebutenolidase of 259 aas and 1 central TMS.

Bacteria
Actinobacteria
CMBL of Blastococcus colisei
4.C.3.1.15









Dienelactone hydrolase family protein of 274 aas.

Bacteria
Proteobacteria
Hydrolase of Bosea thiooxidans
4.C.3.1.16









Alpha/beta fold hydrolase of 280 aas and 1 central TMS.

Bacteria
Actinobacteria
Hydrolase of Streptomyces galbus
4.C.3.2.1









The S-acyl protein thioesterase, ABHD17a (alpha/beta hydrolase domain-containing protein 17A), functions in the deacylation (depalmitoylation) of S-acyl proteins.  See family description for details of how it controls BK channel activities.

Eukaryota
Opisthokonta
ABHD17a S-acyl protein thioesterase of Homo sapiens (Human)  
4.C.3.2.2









alpha/beta-fold Hydrolase of 318 aas and 1 N-terminal TMS plus as many as 6 smaller peaks of hydropathy that could (but may not )be TMSs.

Bacteria
Acidobacteria
Hydrolase of Thermoanaerobaculia bacterium (permafrost metagenome)
4.C.3.2.3









Uncharacterized protein of 278 aas and one N-terminal TMS plus several potential (but not established) less hydrophobic peaks that could be TMSs.

Eukaryota
Opisthokonta
UP of Kluyveromyces dobzhanskii
4.C.3.2.4









alpha/beta-fold Hydrolase of 314 aas and one N-terminal TMS plus 2 or 3 smaller peaks of hydrophobicity that could be TMSs.

Bacteria
Proteobacteria
Hdrolase of Pseudomonas congelans
4.C.3.2.5









αβ-fold hydrolase of 284 aas and 2 smaller peaks of hydrophobicity that could be TMSs.

Bacteria
Proteobacteria
Hydrolase of Escherichia coli
4.C.3.2.6









Phosphatidylserine lipase ABHD16A of 519 aas and 2 + 1 TMSs near the N-terminus plus up to 3 peaks of hydrophobicity that could be additional TMSs.

Eukaryota
Opisthokonta
Lipase of Culex pipiens pallens