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4.D.3.1.8
Cellulose synthase-like protein of 952 aas and about 7 TMSs, 3 (or 4) N-terminal and 6 C-terminal.  May catalyze both beta-1,3 and beta-1,4 glycosidic linkages in beta-D-glucan. Essential for (1,3;1,4)-beta-D-glucans synthesis in grasses and cereals (Poaceae). The mixed-linked glucans (which are not present in walls of dicotyledons or most other monocotyledonous plants) are particularly important constituents of the walls of the starchy endosperm and aleurone cells of cereal grains such as oats, wheat, rice and barley. They can account for up to 70% by weight of the wall.  A  single amino acid within the predicted transmembrane pore domain of CslF6 controls (1-3,1-4)-beta-glucan structure.  The membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide (Jobling 2015).  Residues involved in catalyses and flexibility have been identified (Dimitroff et al. 2016).  These influence theration of 1,3 to 1,4 linkages.

Accession Number:Q84UP7
Protein Name:Probable mixed-linked glucan synthase 6
Length:952
Molecular Weight:105152.00
Species:Oryza sativa subsp. japonica (Rice) [39947]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate Glycosyl residues

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FASTA formatted sequence
1:	MAPAVAGGGG RRNNEGVNGN AAAPACVCGF PVCACAGAAA VASAASSADM DIVAAGQIGA 
61:	VNDESWVAVD LSDSDDAPAA GDVQGALDDR PVFRTEKIKG VLLHPYRVLI FVRLIAFTLF 
121:	VIWRIEHKNP DAMWLWVTSI AGEFWFGFSW LLDQLPKLNP INRVPDLAVL RRRFDHADGT 
181:	SSLPGLDIFV TTADPIKEPI LSTANSILSI LAADYPVDRN TCYLSDDSGM LLTYEAMAEA 
241:	AKFATLWVPF CRKHAIEPRG PESYFELKSH PYMGRAQEEF VNDRRRVRKE YDDFKARING 
301:	LEHDIKQRSD SYNAAAGVKD GEPRATWMAD GSQWEGTWIE QSENHRKGDH AGIVLVLLNH 
361:	PSHARQLGPP ASADNPLDFS GVDVRLPMLV YVAREKRPGC NHQKKAGAMN ALTRASAVLS 
421:	NSPFILNLDC DHYINNSQAL RAGICFMLGR DSDTVAFVQF PQRFEGVDPT DLYANHNRIF 
481:	FDGTLRALDG LQGPIYVGTG CLFRRITLYG FEPPRINVGG PCFPRLGGMF AKNRYQKPGF 
541:	EMTKPGAKPV APPPAATVAK GKHGFLPMPK KAYGKSDAFA DTIPRASHPS PYAAEAAVAA 
601:	DEAAIAEAVM VTAAAYEKKT GWGSDIGWVY GTVTEDVVTG YRMHIKGWRS RYCSIYPHAF 
661:	IGTAPINLTE RLFQVLRWST GSLEIFFSRN NPLFGSTFLH PLQRVAYINI TTYPFTALFL 
721:	IFYTTVPALS FVTGHFIVQR PTTMFYVYLA IVLGTLLILA VLEVKWAGVT VFEWFRNGQF 
781:	WMTASCSAYL AAVLQVVTKV VFRRDISFKL TSKLPAGDEK KDPYADLYVV RWTWLMITPI 
841:	IIILVNIIGS AVAFAKVLDG EWTHWLKVAG GVFFNFWVLF HLYPFAKGIL GKHGKTPVVV 
901:	LVWWAFTFVI TAVLYINIPH IHGPGRHGAA SPSHGHHSAH GTKKYDFTYA WP