| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.108.1.1 | The ER curvature-stabilizing protein, YOP1, of 180 aas and 4 probable TMSs in a 2 + 2 arrangement (Powers et al. 2017). See family description for details. | Eukaryota |
Fungi, Ascomycota | YOP1 of Saccharomyces cerevisiae (Baker's yeast) |
|
8.A.108.1.2 | Uncharacterized receptor expression-enhancing protein 3-like isoform X2 of 229 aas and 3 putative TMSs. | Eukaryota |
Metazoa, Chordata | UP of Neolamprologus brichardi |
|
8.A.108.1.3 | Uncharacterized protein of 221aas and 3 TMSs | Eukaryota |
Metazoa, Arthropoda | UP of Sarcophaga bullata |
|
8.A.108.1.4 | Uncharacterized protein of 197 aas and 3 TMSs | Eukaryota |
Oomycota | UP of Aphanomyces invadans |
|
8.A.108.1.5 | Uncharacterized protein of 161 aas and 2 - 4 TMSs. If 4 TMSs as for other family members, they occur in a 2 + 2 TMS arrangement. | Eukaryota |
Metazoa, Nematoda | UP of Caenorhabditis elegans |
|
8.A.108.1.6 | Uncharacterized protein of 270 aas and (3 or) 4 TMSs with a possible 1 + 2 + 1 TMS arrangement. | Eukaryota |
Fungi, Basidiomycota | UP of Malassezia vespertilionis |
|
8.A.108.1.7 | S-phase cyclin A-associated protein in the endoplasmic reticulum, isoform X1 of 415 aas and 3 N-terminal TMSs in a 1 + 2 TMS arrangement. | Eukaryota |
Viridiplantae, Streptophyta | Cyclin A of Sesamum indicum |
|
8.A.108.1.8 | Atlastine, REEP1 or SPG31 of 201 aas and 3 N-terminal TMSs in a 1 + 2 TMS arrangement. The protein is required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton and may also enhance the cell surface expression of odorant receptors (Park et al. 2010). It may also play a role in long-term axonal maintenance (Falk et al. 2014) | Eukaryota |
Metazoa, Chordata | REEP1 of Homo sapiens (Human) |
|
8.A.108.1.9 | Receptor Expression-Enhancing Protein 6, REEP6, of 211 aas and probably 4 TMSs in a 2 + 2 TMS arrangement. The clinical and biological effects of REEP6 on tongue squamous cell carcinoma (TSCC) have been studied (Tseng et al. 2023). REEP6 controls the expression or transport of a subset of proteins/receptors. Thus, REEP6 is involved in the malignancy of TSCC and might serve as a potential diagnostic/prognostic biomarker and therapeutic target for TSCC patients (Tseng et al. 2023). | Eukaryota |
Metazoa, Chordata | REEP6 of Homo sapiens |