8.A.115. The Transmembrane Protein 223 (TMEM223) Family
TMEM223 regulates the activity of CaV2.2 (Mallmann et al. 2019). It lowers the average current density, accelerates the kinetics of cumulative current inactivation and slows the kinetics of recovery from inactivation. TMEM223 interacts directly with Cav2.2 and negatively modulate Ca2+ entry via this channel protein, and this interaction is required for proper transmitter release and/or for dendritic plasticity under physiological conditions (Mallmann et al. 2019).