8.A.117.1.6
Neuroligin-3, NLGN-3, of 848 aas and up to 8 TMSs in a possible 2 + 2 + 2 + 2 TMS arrangement. It is a cell surface protein involved in
cell-cell-interactions via its interactions with neurexin family
members. It plays a role in synapse function and synaptic signal
transmission, and may mediate its effects by clustering other synaptic
proteins. It may also promote the initial formation of synapses, but is not
essential for this. It may also play a role in glia-glia or glia-neuron
interactions in the developing peripheral nervous system. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins (Graf et al. 2004). Neuroligin 3 from the common cutworm enhances the GABA-induced current of recombinant SlRDL1 channels (TC family 1.A.9) (Wang et al. 2021).
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| Accession Number: | Q9NZ94 |
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| Protein Name: | Neuroligin-3 |
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| Length: | 848 |
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| Molecular Weight: | 93895.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK LRGARVPLPS
61: EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT HFPPVCPQNI HTAVPEVMLP
121: VWFTANLDIV ATYIQEPNED CLYLNVYVPT EDVKRISKEC ARKPNKKICR KGGSGAKKQG
181: EDLADNDGDE DEDIRDSGAK PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG
241: VLGFLSTGDQ AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS
301: HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD CLRQKSAKEL
361: VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD IMLGVNQGEG LKFVEGVVDP
421: EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL RETIKFMYTD WADRDNPETR RKTLVALFTD
481: HQWVEPSVVT ADLHARYGSP TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD
541: LFPCNFSKND VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD
601: QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP DTTHSSHITR
661: RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN PRDYSTELSV TIAVGASLLF
721: LNVLAFAALY YRKDKRRQEP LRQPSPQRGA GAPELGAAPE EELAALQLGP THHECEAGPP
781: HDTLRLTALP DYTLTLRRSP DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP
841: HSHSTTRV