TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.117.1.1









Neuroligan-2 of 835 aas and 2 TMSs, one N-terminal and one near the C-terminus. Postsynaptic proteins localize to excitatory (neuroligin-1) and inhibitory synapses (neuroligin-2 and collybistin). The lack of neuroligin-1 leads to deficient synaptic plasticity and reduced excitation but normal granule cell output, but the lack of neuroligin-2 and/or collybistin reduces inhibition, resulting in a shift towards excitation of the dentate circuitry (Jedlicka et al. 2018). Neuroligan-2 is a constituent of the GABAA receptor (TC# 1.A.9.5.2) (Tomita 2019). It might be a biomarker for the diagnosis of encephalitis (Xiong et al. 2021).

Eukaryota
Metazoa, Chordata
Neuroligin 2 of Homo sapiens
8.A.117.1.2









Neuroligin-1, NGLN1, of 840 aas and 2 TMSs, N-terminal and near the C-terminus.  NGLN1 plays a role in memory by influencing synaptic transmission (Katzman and Alberini 2018).

Eukaryota
Metazoa, Chordata
NGLN1 of Homo sapiens
8.A.117.1.3









 

Neuroliligin-4, NLGN4, of 816 aas and 2 TMSs, N- and C-terminal.  Plays a role in autism by promoting glycinergic synaptic transmission in brainstem synapses (Zhang et al. 2018).

Eukaryota
Metazoa, Chordata
NLGN4 of Homo sapiens
8.A.117.1.4









Neuroligin-2, Nlg2, of 1248 aas and at least 2 TMSs, N-terminal and near the C-terminus, but as many as 4 more potential TMSs can be found near the N-terminus. Required for synapse formation and function (Sun et al. 2011).

Eukaryota
Metazoa, Arthropoda
NLGN2 of Drosophila melanogaster
8.A.117.1.5









Neuroligin-1 (NGLN1) of 798 aas and 2 TMSs. Iit is involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins, and it plays a role in the clustering of the GABA(A) receptor Unc-49 at postsynaptic sites in neuromuscular junctions via interactions with madd-4 and neurexin, nrx-1. It is is thereby required for normal GABAergic synaptic transmission (Maro et al. 2015, Tu et al. 2015).

Eukaryota
Metazoa, Nematoda
NGLN1 of Caenorhabditis elegans
8.A.117.1.6









Neuroligin-3, NLGN-3, of 848 aas and up to 8 TMSs in a possible 2 + 2 + 2 + 2 TMS arrangement. It is a cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. It plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. It may also promote the initial formation of synapses, but is not essential for this. It may also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins (Graf et al. 2004). Neuroligin 3 from the common cutworm enhances the GABA-induced current of recombinant SlRDL1 channels (TC family 1.A.9) (Wang et al. 2021).

 

Eukaryota
Metazoa, Chordata
Neuroligin-3 of Homo sapiens