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8.A.125.  The Cleft Lip and Palate Transmembrane Protein 1 (Clptm1) Family

GABAAR-associated proteins include the Cleft lip and palate transmembrane protein 1 (Clptm1) which interacts with all GABAAR subunits and promotes GABAAR trapping in the endoplasmic reticulum (Ge et al. 2018). Overexpression of Clptm1 reduces GABAAR-mediated currents in cultured hippocampal neurons and in brain with no effect on glycine or AMPA receptor-mediated currents. Conversely, knockdown of Clptm1 increased phasic and tonic inhibitory transmission with no effect on excitatory synaptic transmission. Furthermore, altering the expression level of Clptm1 mimicked activity-induced inhibitory synaptic scaling. Thus, in complement to other GABAAR-associated proteins that promote receptor surface expression, Clptm1 limits GABAAR forward trafficking and regulates inhibitory homeostatic plasticity (Ge et al. 2018).

References associated with 8.A.125 family:

Ge, Y., Y. Kang, R.M. Cassidy, K.M. Moon, R. Lewis, R.O.L. Wong, L.J. Foster, and A.M. Craig. (2018). Clptm1 Limits Forward Trafficking of GABA Receptors to Scale Inhibitory Synaptic Strength. Neuron. 97: 596-610.e8. 29395912
Wang, Y., A.K. Menon, Y. Maki, Y.S. Liu, Y. Iwasaki, M. Fujita, P.A. Guerrero, D.V. Silva, P.H. Seeberger, Y. Murakami, and T. Kinoshita. (2022). Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis. Proc. Natl. Acad. Sci. USA 119: e2115083119. 35344438
Yamamoto, K., A. Okamoto, S. Isonishi, K. Ochiai, and Y. Ohtake. (2001). A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Biochem. Biophys. Res. Commun. 280: 1148-1154. 11162647