8.A.137. The Clathrin (Clathrin) Family
Clathrin impacts Wnt/beta-catenin signaling by controlling exocytosis of transmembrane proteins including cadherins and Wnt co-receptors that together control the membrane-bound and soluble pools of beta-catenin. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. It acts as a component of the TACC3/ch-TOG/clathrin complex, proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as an inter-microtubule bridge (Royle et al. 2005, Royle and Lagnado 2006, Booth et al. 2011). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (Cheeseman et al. 2013). It also plays a role in early autophagosome formation (Ravikumar et al. 2010).