| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.140.1.1 | Inositol 1,4,5-triphosphate receptor associated 2, IRAG2, JAW1, LRMP, of 555 aas and one C-terminal TMS. It plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules which occurs in a transporter associated with antigen processing (TAP)-independent manner. It may also play a role in taste signal transduction via ITPR3 as well as during fertilization in pronucleus congression and fusion. It regulates HCN4 channels (Peters et al. 2020). A recurrent missense variant in ITPR3 causes demyelinating Charcot-Marie-Tooth disease with variable severity (Beijer et al. 2025). | Eukaryota |
Metazoa, Chordata | HCN4 channel regulator, IRAG2 of Homo sapiens |
|
8.A.140.1.2 | Uncharacterized protein of 959 aas and 2 TMSs, one about one-fourth from the N-terminus and one at the C-terminus. | Eukaryota |
Metazoa, Chordata | UP of Pygoscelis adeliae (Adelie penguin) |
|
8.A.140.1.3 | Lymphoid-restricted membrane protein-like, LRMP-L, isoform X1 of 1370 aas and one C-terminal TMS. | Eukaryota |
Metazoa, Cnidaria | LRMP-L of Dendronephthya gigantea |
|
8.A.140.1.4 | Uncharacterized protein of 706 aas and one C-terminal TMS. | Eukaryota |
Metazoa, Cnidaria | UP of Hydra vulgaris (swiftwater hydra) |
|
8.A.140.2.1 | Uncharacterized protein of 475 aas and one C-terminal TMS [Penaeus vannamei | Eukaryota |
Metazoa, Arthropoda | UP of Penaeus vannamei |
|
8.A.140.2.2 | Uncharacterized protein of 706 aas and 1 TMS, about one-third from the C-terminus. | Eukaryota |
Metazoa, Arthropoda | UP of Lamprigera yunnana (firefly) |