TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.143.1.1









Transmembrane protein 132A, TMEM132A, of 1032 aas and 2 TMSs, N-terminal and near the C-terminus. It may play a role in embryonic and postnatal development of the brain. Increased resistance to cell death is induced by serum starvation in cultured cells. It regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (Sanchez-Pulido and Ponting 2018). It may play a role in Lowe syndrome (LS) (Liu et al. 2020Liu et al. 2020).

Eukaryota
Metazoa, Chordata
TMEM132A of Homo sapiens
8.A.143.1.2









Transmembrane protein 132E, TMEM132E of 1610 aas and 2 - 4 TMSs.

Eukaryota
Metazoa, Arthropoda
TMEM132E of Danaus plexippus plexippus
8.A.143.1.3









Uncharacterized protein of 1176 aas and 1 TMS near the C-terminus.

Eukaryota
Metazoa, Annelida
UP of Helobdella robusta
8.A.143.1.4









Uncharacterized protein of 1948 aas and 2 TMSs, one at the N-terminus, and one near the C-terminus.

Eukaryota
Metazoa, Platyhelminthes
UP of Opisthorchis viverrini
8.A.143.1.5









TMEM132e of 1074 aas and 2 TMSs.  Ion channel function for the α9α10 nicotinic acetylcholine receptor (1.A.9.1.22) requires an auxiliary subunit, which can be transmembrane inner ear (TMIE; TC# 8.A,116) or TMEM132e. Both of these single-pass transmembrane proteins are enriched in hair cells and underlie nonsyndromic human deafness (Gu et al. 2020).

Eukaryota
Metazoa, Chordata
TMEM132e of Homo sapiens