TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.147.1.1









Tpx1 is a peroxiredoxin that binds hemin and regulates the heme-iron/siderophore-iron transporter 3, Str3 (TC# 2.A.1.16.9). Tpx1 (Q74887; 192 aas and 0 - 2 possible TMSs), is a high affinity binding partner of Str3 (Normant et al. 2020).

Eukaryota
Fungi, Ascomycota
Str3 of Schizosaccharomyces pombe (Fission yeast)
8.A.147.1.2









Peroxiredoxin of 180 aas and 0 - 2 TMSs.

Bacteria
Bacillota
Peroxiredoxin of Bacillus subtilis
8.A.147.1.3









Peroxiredoxin 6 (Prdx6), of 224 aas and 0 TMSs, is a multifunctional eukaryotic antioxidant enzyme. Mammalian Prdx6 possesses peroxidase activity against a wide range of organic and inorganic hydroperoxides as well as phospholipase A2 (aiPLA2) activity, which plays an important role in the reduction of oxidized phospholipids and cell membrane remodeling (Chen et al. 2000). Exogenous Prdx6 is able to penetrate inside the cell via its phospholipase activity (Sharapov et al. 2022).

Eukaryota
Metazoa, Chordata
Prdx6 of Homo sapiens