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8.A.157.  The Optineurin (OPTN) Family 

Optineurin plays an important role in the maintenance of the Golgi complex, in membrane trafficking and in exocytosis, through its interaction with myosin VI and Rab8 (Fifita et al. 2017). It links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (Fifita et al. 2017). Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway (Meng et al. 2012).

 

References associated with 8.A.157 family:

Fifita, J.A., K.L. Williams, V. Sundaramoorthy, E.P. Mccann, G.A. Nicholson, J.D. Atkin, and I.P. Blair. (2017). A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro. Amyotroph Lateral Scler Frontotemporal Degener 18: 126-133. 27534431
Meng, Q., J. Lv, H. Ge, L. Zhang, F. Xue, Y. Zhu, and P. Liu. (2012). Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway. Mol Biol Rep 39: 5867-5873. 22422156