8.A.157. The Optineurin (OPTN) Family
Optineurin plays an important role in the maintenance of the Golgi complex, in membrane trafficking and in exocytosis, through its interaction with myosin VI and Rab8 (Fifita et al. 2017). It links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (Fifita et al. 2017). Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway (Meng et al. 2012).