8.A.159.1.10
MIR2 (K5) of human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). E3 ubiquitin-protein ligase promotes ubiquitination and subsequent degradation of host MHC-I, CD86, ICAM1 and CD1D molecules, to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. It binds target molecules through transmembrane interactions. Different features of CD86 to downregulate surface expression are responsible for binding (Trenker et al. 2021).