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View Proteins belonging to: The MARCH Ubiquitin Ligase (MARCH) Family

8.A.159. The MARCH Ubiquitin Ligase (MARCH) Family

Membrane-associated RING-cysteine-histidine (CH) (MARCH) ubiquitin ligases belong to a RING finger domain E3 ligases family. Eleven members have been found in the MARCH family, which are MARCH 1 to 11. The members of the MARCH family are widely distributed and involve in a variety of cellular functions, including regulation of the immune system, transmembrane transport of proteins, protein stability, endoplasmic reticulum-related degradation, and endosome protein transport. Several studies have shown that MARCH affects viral replication through various mechanisms by regulating the activity of signaling molecules and their expression in the antiviral innate immune responses. The complex roles of MARCH ligases in the antiviral innate immune signaling pathway and its impact on viral replication in host immune defense systems have been reviewed (Zheng 2021).

View Proteins belonging to: The MARCH Ubiquitin Ligase (MARCH) Family

References associated with 8.A.159 family:

Bartee, E., M. Mansouri, B.T. Hovey Nerenberg, K. Gouveia, and K. Früh. (2004). Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J. Virol. 78: 1109-1120. 14722266

De Gassart, A., V. Camosseto, J. Thibodeau, M. Ceppi, N. Catalan, P. Pierre, and E. Gatti. (2008). MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl. Acad. Sci. USA 105: 3491-3496. 18305173

Hassink, G., M. Kikkert, S. van Voorden, S.J. Lee, R. Spaapen, T. van Laar, C.S. Coleman, E. Bartee, K. Früh, V. Chau, and E. Wiertz. (2005). TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Biochem. J. 388: 647-655. 15673284

Lapaque, N., M. Jahnke, J. Trowsdale, and A.P. Kelly. (2009). The HLA-DRalpha chain is modified by polyubiquitination. J. Biol. Chem. 284: 7007-7016. 19117940

Nakamura, N., H. Fukuda, A. Kato, and S. Hirose. (2005). MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Mol. Biol. Cell 16: 1696-1710. 15689499

Trenker, R., X. Wu, J.V. Nguyen, S. Wilcox, A.F. Rubin, M.E. Call, and M.J. Call. (2021). Human and viral membrane-associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression. J. Biol. Chem. 297: 100900. 34157285

Zavacki, A.M., R. Arrojo E Drigo, B.C. Freitas, M. Chung, J.W. Harney, P. Egri, G. Wittmann, C. Fekete, B. Gereben, and A.C. Bianco. (2009). The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol. Cell Biol. 29: 5339-5347. 19651899

Zelcer, N., L.J. Sharpe, A. Loregger, I. Kristiana, E.C. Cook, L. Phan, J. Stevenson, and A.J. Brown. (2014). The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. Mol. Cell Biol. 34: 1262-1270. 24449766

Zheng, C. (2021). The emerging roles of the MARCH ligases in antiviral innate immunity. Int J Biol Macromol 171: 423-427. [Epub: Ahead of Print] 33428955