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8.A.159.  The MARCH Ubiquitin Ligase (MARCH) Family

Membrane-associated RING-cysteine-histidine (CH) (MARCH) ubiquitin ligases belong to a RING finger domain E3 ligases family. Eleven members have been found in the MARCH family, which are MARCH 1 to 11. The members of the MARCH family are widely distributed and involve in a variety of cellular functions, including regulation of the immune system, transmembrane transport of proteins, protein stability, endoplasmic reticulum-related degradation, and endosome protein transport. Several studies have shown that MARCH affects viral replication through various mechanisms by regulating the activity of signaling molecules and their expression in the antiviral innate immune responses. The complex roles of MARCH ligases in the antiviral innate immune signaling pathway and its impact on viral replication in host immune defense systems have been reviewed (Zheng 2021).

References associated with 8.A.159 family:

Bartee, E., M. Mansouri, B.T. Hovey Nerenberg, K. Gouveia, and K. Früh. (2004). Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J. Virol. 78: 1109-1120. 14722266
De Gassart, A., V. Camosseto, J. Thibodeau, M. Ceppi, N. Catalan, P. Pierre, and E. Gatti. (2008). MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl. Acad. Sci. USA 105: 3491-3496. 18305173
Hassink, G., M. Kikkert, S. van Voorden, S.J. Lee, R. Spaapen, T. van Laar, C.S. Coleman, E. Bartee, K. Früh, V. Chau, and E. Wiertz. (2005). TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Biochem. J. 388: 647-655. 15673284
Lapaque, N., M. Jahnke, J. Trowsdale, and A.P. Kelly. (2009). The HLA-DRalpha chain is modified by polyubiquitination. J. Biol. Chem. 284: 7007-7016. 19117940
Nakamura, N., H. Fukuda, A. Kato, and S. Hirose. (2005). MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Mol. Biol. Cell 16: 1696-1710. 15689499
Zavacki, A.M., R. Arrojo E Drigo, B.C. Freitas, M. Chung, J.W. Harney, P. Egri, G. Wittmann, C. Fekete, B. Gereben, and A.C. Bianco. (2009). The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol. Cell Biol. 29: 5339-5347. 19651899
Zelcer, N., L.J. Sharpe, A. Loregger, I. Kristiana, E.C. Cook, L. Phan, J. Stevenson, and A.J. Brown. (2014). The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. Mol. Cell Biol. 34: 1262-1270. 24449766
Zheng, C. (2021). The emerging roles of the MARCH ligases in antiviral innate immunity. Int J Biol Macromol 171: 423-427. [Epub: Ahead of Print] 33428955