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8.A.159.1.11 The E3 ubiquitin-protein ligase of 910 aas and 15 TMSs in a 3 + 6 + 6 TMS arrangement. The last two 6 TMS units are probably duplicates of each other. The ligase promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (Hassink et al. 2005).
Accession Number:	O60337
Protein Name:	E3 ubiquitin-protein ligase MARCHF6
Length:	910
Molecular Weight:	102545.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	15
Location¹ / Topology² / Orientation³:	Endoplasmic reticulum membrane¹ / Multi-pass membrane protein²
Substrate	protein polypeptide chain

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE YCELCKHRFA 
61:	FTPIYSPDMP SRLPIQDIFA GLVTSIGTAI RYWFHYTLVA FAWLGVVPLT ACRIYKCLFT 
121:	GSVSSLLTLP LDMLSTENLL ADCLQGCFVV TCTLCAFISL VWLREQIVHG GAPIWLEHAA 
181:	PPFNAAGHHQ NEAPAGGNGA ENVAADQPAN PPAENAVVGE NPDAQDDQAE EEEEDNEEED 
241:	DAGVEDAADA NNGAQDDMNW NALEWDRAAE ELTWERMLGL DGSLVFLEHV FWVVSLNTLF 
301:	ILVFAFCPYH IGHFSLVGLG FEEHVQASHF EGLITTIVGY ILLAITLIIC HGLATLVKFH 
361:	RSRRLLGVCY IVVKVSLLVV VEIGVFPLIC GWWLDICSLE MFDATLKDRE LSFQSAPGTT 
421:	MFLHWLVGMV YVFYFASFIL LLREVLRPGV LWFLRNLNDP DFNPVQEMIH LPIYRHLRRF 
481:	ILSVIVFGSI VLLMLWLPIR IIKSVLPNFL PYNVMLYSDA PVSELSLELL LLQVVLPALL 
541:	EQGHTRQWLK GLVRAWTVTA GYLLDLHSYL LGDQEENENS ANQQVNNNQH ARNNNAIPVV 
601:	GEGLHAAHQA ILQQGGPVGF QPYRRPLNFP LRIFLLIVFM CITLLIASLI CLTLPVFAGR 
661:	WLMSFWTGTA KIHELYTAAC GLYVCWLTIR AVTVMVAWMP QGRRVIFQKV KEWSLMIMKT 
721:	LIVAVLLAGV VPLLLGLLFE LVIVAPLRVP LDQTPLFYPW QDWALGVLHA KIIAAITLMG 
781:	PQWWLKTVIE QVYANGIRNI DLHYIVRKLA APVISVLLLS LCVPYVIASG VVPLLGVTAE 
841:	MQNLVHRRIY PFLLMVVVLM AILSFQVRQF KRLYEHIKND KYLVGQRLVN YERKSGKQGS 
901:	SPPPPQSSQE

8.A.159.1.11
The E3 ubiquitin-protein ligase of 910 aas and 15 TMSs in a 3 + 6 + 6 TMS arrangement. The last two 6 TMS units are probably duplicates of each other. The ligase promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (Hassink et al. 2005).

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8.A.159.1.11The E3 ubiquitin-protein ligase of 910 aas and 15 TMSs in a 3 + 6 + 6 TMS arrangement. The last two 6 TMS units are probably duplicates of each other. The ligase promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (Hassink et al. 2005).

Cross database links:

External Searches:

Analyze:

8.A.159.1.11
The E3 ubiquitin-protein ligase of 910 aas and 15 TMSs in a 3 + 6 + 6 TMS arrangement. The last two 6 TMS units are probably duplicates of each other. The ligase promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (Hassink et al. 2005).