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8.A.159.1.3
MARCH2 (MARCHII) of 246 aas and 2 TMSs, near the C-terminus of the protein. It is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (Nakamura et al. 2005). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates and may be involved in endosomal trafficking through interaction with STX6 (Bartee et al. 2004).

Accession Number:Q9P0N8
Protein Name:E3 ubiquitin-protein ligase MARCHF2
Length:246
Molecular Weight:26995.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate protein

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FASTA formatted sequence
1:	MTTGDCCHLP GSLCDCSGSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD 
61:	GPFCRICHEG ANGECLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR 
121:	PLTEWLKDPG PRTEKRTLCC DMVCFLFITP LAAISGWLCL RGAQDHLRLH SQLEAVGLIA 
181:	LTIALFTIYV LWTLVSFRYH CQLYSEWRKT NQKVRLKIRE ADSPEGPQHS PLAAGLLKKV 
241:	AEETPV