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8.A.160.  The Catenin (Catenin) Family 

Catenin δ-1 is a key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of C-, E- and N-cadherins, being critical for their surface stability (Davis et al. 2003, Ishiyama et al. 2010). Beside cell-cell adhesion, it regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (Daniel and Reynolds 1999, Ishiyama et al. 2010). It is implicated in both cell transformation by SRC and ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (Hosking et al. 2007). Mutations in the beta-catenin gene (CTNNB1), lead to aberrant immunohistochemical expression of beta-catenin, and this represents a key mechanism of WNT/beta-catenin pathway alteration in ovarian cancer (Angelico et al. 2021). Beta-catenin and AQP1 are co-expressed in a sub-group of ovarian tumors and play important roles in carcinogenesis (Angelico et al. 2021).

p120 catenin recruits human papillomavirus (HPV) to the transmembrane protease, gamma-secretase, to promote virus infection (Harwood et al. 2020). During internalization and trafficking, HPV moves from the cell surface to the endosome where γ-secretase promotes insertion of the viral L2 capsid protein into the endosomal membrane. Protrusion of L2 through the endosomal membrane into the cytosol allows the recruitment of cytosolic host factors that target the virus to the Golgi, en route for productive infection. Cytosolic p120 catenin, likely via an unidentified transmembrane protein, interacts with HPV at early time-points during viral internalization and trafficking. In the endosome, p120 is not required for low pH-dependent disassembly of the HPV L1 capsid protein from the incoming virion. Rather, p120 is required for HPV to interact with gamma-secretase - an interaction that ensures the virus is transported along a productive route (Harwood et al. 2020).

 

References associated with 8.A.160 family:

Abe, K. and M. Takeichi. (2008). EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc. Natl. Acad. Sci. USA 105: 13-19. 18093941
Akiyama, H., J.P. Lyons, Y. Mori-Akiyama, X. Yang, R. Zhang, Z. Zhang, J.M. Deng, M.M. Taketo, T. Nakamura, R.R. Behringer, P.D. McCrea, and B. de Crombrugghe. (2004). Interactions between Sox9 and β-catenin control chondrocyte differentiation. Genes Dev. 18: 1072-1087. 15132997
Angelico, G., A. Ieni, R. Caltabiano, A. Santoro, F. Inzani, S. Spadola, G. Tuccari, A. Macrì, and G.F. Zannoni. (2021). Evaluation of Beta-Catenin Subcellular Localization and Water Channel Protein AQP1 Expression as Predictive Markers of Chemo-Resistance in Ovarian High-Grade Serous Carcinoma: Comparative Study between Preoperative Peritoneal Biopsies and Surgical Samples. Diagnostics (Basel) 11:. 33807998
Daniel, J.M. and A.B. Reynolds. (1999). The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol. Cell Biol. 19: 3614-3623. 10207085
Davis, M.A., R.C. Ireton, and A.B. Reynolds. (2003). A core function for p120-catenin in cadherin turnover. J. Cell Biol. 163: 525-534. 14610055
Harwood, M.C., A.J. Dupzyk, T. Inoue, D. DiMaio, and B. Tsai. (2020). p120 catenin recruits HPV to γ-secretase to promote virus infection. PLoS Pathog 16: e1008946. 33085724
Hosking, C.R., F. Ulloa, C. Hogan, E.C. Ferber, A. Figueroa, K. Gevaert, W. Birchmeier, J. Briscoe, and Y. Fujita. (2007). The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol. Biol. Cell 18: 1918-1927. 17344476
Ishiyama, N., S.H. Lee, S. Liu, G.Y. Li, M.J. Smith, L.F. Reichardt, and M. Ikura. (2010). Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell 141: 117-128. 20371349
Kim, S., H.I. Choi, H.J. Ryu, J.H. Park, M.D. Kim, and S.Y. Kim. (2004). ARIA, an Arabidopsis arm repeat protein interacting with a transcriptional regulator of abscisic acid-responsive gene expression, is a novel abscisic acid signaling component. Plant Physiol. 136: 3639-3648. 15516505
Yamada, S., S. Pokutta, F. Drees, W.I. Weis, and W.J. Nelson. (2005). Deconstructing the cadherin-catenin-actin complex. Cell 123: 889-901. 16325582