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8.A.163.  The HSP90/CDC37 (HSP90/CDC37) Family 

The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication (Heider et al. 2021).  Cereblon (CRBN), the target of immunomodulatory drugs (IMiDs), is a co-chaperone that specifically determines chaperone activity of HSP90 toward transmembrane proteins by means of counteracting AHA1. This function is abrogated by IMiDs, which disrupt the interaction of CRBN with HSP90. Among the multiple transmembrane protein clients of CRBN-AHA1-HSP90 revealed by cell surface proteomics, is the amino acid transporter LAT1/CD98hc as a determinant of IMiD activity in multiple myeloma (MM) and present an Anticalin-based CD98hc radiopharmaceutical for MM radio-theranostics. These data establish the CRBN-AHA1-HSP90 axis in the biogenesis of transmembrane proteins, link IMiD activity to tumor metabolism, and nominate CD98hc and LAT1 as attractive diagnostic and therapeutic targets in MM (Heider et al. 2021).

References associated with 8.A.163 family:

Chadli, A., J.D. Graham, M.G. Abel, T.A. Jackson, D.F. Gordon, W.M. Wood, S.J. Felts, K.B. Horwitz, and D. Toft. (2006). GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol. Cell Biol. 26: 1722-1730. 16478993
Heider, M., R. Eichner, J. Stroh, V. Morath, A. Kuisl, J. Zecha, J. Lawatscheck, K. Baek, A.K. Garz, M. Rudelius, F.C. Deuschle, U. Keller, S. Lemeer, M. Verbeek, K.S. Götze, A. Skerra, W.A. Weber, J. Buchner, B.A. Schulman, B. Kuster, V. Fernández-Sáiz, and F. Bassermann. (2021). The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Mol. Cell 81: 1170-1186.e10. 33571422
Retzlaff, M., M. Stahl, H.C. Eberl, S. Lagleder, J. Beck, H. Kessler, and J. Buchner. (2009). Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep 10: 1147-1153. 19696785
Richter, K., J. Soroka, L. Skalniak, A. Leskovar, M. Hessling, J. Reinstein, and J. Buchner. (2008). Conserved conformational changes in the ATPase cycle of human Hsp90. J. Biol. Chem. 283: 17757-17765. 18400751