8.A.168.1.1 Glycophorin A (GYPA or GPA) of 150 aas and 2 TMSs, one N-terminal and one near the C-terminus of the protein. Red blood cell sialoglycoproteins (glycophorins) play an important role in invasion by Plasmodium falciparum (Pasvol et al. 1992), but they also regulate the activities of several transport systems (see GP family description and Takakuwa 2001). GpA dimerization has been measured using molecular dynamics-based approaches that agree with experiments, and this allows the protein-protein binding affinities in membranes (Blazhynska et al. 2023).
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Accession Number: | P02724 |
Protein Name: | Glycophorin-A |
Length: | 150 |
Molecular Weight: | 16331.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
Substrate |
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1: MYGKIIFVLL LSEIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNDTHKR DTYAATPRAH
61: EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM AGVIGTILLI SYGIRRLIKK
121: SPSDVKPLPS PDTDVPLSSV EIENPETSDQ