8.A.17.1.1
Sodium channel ß1 (β-1, beta-1) subunit.  This subunit can interact with and regulate the activity of the K⁺ channel, Kv10.1 of the KCNH family (TC# 1.A.1.2.17), as well as of Na⁺ channels (Kubota et al. 2017). Both beta1 and beta3 subunits regulate channel gating, expression, and pharmacology. Beta1 regulates NaV1.5 by modulating the 4th voltage-sensing domain, DIV-VSD, whereas beta3 alters channel kinetics mainly through the DIII-VSD interaction (Zhu et al. 2017). An SCN1B variant affects both cardiac-type (NaV1.5) and brain-type (NaV1.1) sodium currents and contributes to complex concomitant brain and cardiac disorders (Martinez-Moreno et al. 2020). Mice null for Scn1b, which encodes NaV beta1 and beta1b subunits, have defects in neuronal development and excitability, spontaneous generalized seizures, cardiac arrhythmias, and early mortality.  A novel role of Na_Vβ3 in endothelial function and cell alignment as an actor in shear stress vasculoprotective intracellular pathway through autophagy modulation has been proposed (Réthoré et al. 2025).