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8.A.171.1.1 Transmembrane protein 168, TMEM168, of 697 aas and 13 or 14 TMS in a 4 + 5 or 6 + 3 TMS arrangement. TMEM168 mutations reduce cardiomyocyte cell surface expression of Nav1.5 (TC# 1.A.1.10.3) through alphaB-crystallin intracellular dynamics (see family description).
Accession Number:	Q9H0V1
Protein Name:	Transmembrane protein 168
Length:	697
Molecular Weight:	79755.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA 
61:	NSLILVIFIL GLFVLGIASI LYYYFSMEAA SLSLSNLWFG FLLGLLCFLD NSSFKNDVKE 
121:	ESTKYLLLTS IVLRILCSLV ERISGYVRHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV 
181:	ILLVVALAML IIDLRMKSFL AIPNLVIFAV LLFFSSLETP KNPIAFACFF ICLITDPFLD 
241:	IYFSGLSVTE RWKPFLYRGR ICRRLSVVFA GMIELTFFIL SAFKLRDTHL WYFVIPGFSI 
301:	FGIFWMICHI IFLLTLWGFH TKLNDCHKVY FTHRTDYNSL DRIMASKGMR HFCLISEQLV 
361:	FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT 
421:	NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK 
481:	LKAFLELRTV DGPRHDTYIL YYSGHTHGTG EWALAGGDTL RLDTLIEWWR EKNGSFCSRL 
541:	IIVLDSENST PWVKEVRKIN DQYIAVQGAE LIKTVDIEEA DPPQLGDFTK DWVEYNCNSS 
601:	NNICWTEKGR TVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL 
661:	NLFWICKTCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS

8.A.171.1.1
Transmembrane protein 168, TMEM168, of 697 aas and 13 or 14 TMS in a 4 + 5 or 6 + 3 TMS arrangement. TMEM168 mutations reduce cardiomyocyte cell surface expression of Nav1.5 (TC# 1.A.1.10.3) through alphaB-crystallin intracellular dynamics (see family description).

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8.A.171.1.1Transmembrane protein 168, TMEM168, of 697 aas and 13 or 14 TMS in a 4 + 5 or 6 + 3 TMS arrangement. TMEM168 mutations reduce cardiomyocyte cell surface expression of Nav1.5 (TC# 1.A.1.10.3) through alphaB-crystallin intracellular dynamics (see family description).

Cross database links:

External Searches:

Analyze:

8.A.171.1.1
Transmembrane protein 168, TMEM168, of 697 aas and 13 or 14 TMS in a 4 + 5 or 6 + 3 TMS arrangement. TMEM168 mutations reduce cardiomyocyte cell surface expression of Nav1.5 (TC# 1.A.1.10.3) through alphaB-crystallin intracellular dynamics (see family description).