αA-Crystallin, CryAA, CryA2, HSPB5, or αBC, of 175 aas and probably 0 TMSs. Both crystallins are regulated by phosphorylation (Thornell and Aquilina 2015). It is a member of the small heat-shock protein family of proteins that respond to various stressful conditions. αBC also is found outside the lens in various non-ocular tissues and acts as a molecular chaperone by preventing aggregation of proteins, inhibits apoptosis and inflammation, and maintains cytoskeletal architecture (Reddy and Reddy 2015).