8.A.172.1.2 αA-Crystallin, CryAA, CryA2, HSPB5, or αBC, of 175 aas and probably 0 TMSs. Both crystallins are regulated by phosphorylation (Thornell and Aquilina 2015). It is a member of the small heat-shock protein family of proteins that respond to various
stressful conditions. αBC also is found outside the lens in various
non-ocular tissues and acts as a molecular chaperone by preventing
aggregation of proteins, inhibits apoptosis and inflammation, and
maintains cytoskeletal architecture (Reddy and Reddy 2015).
|
Accession Number: | P02489 |
Protein Name: | Alpha-crystallin A chain |
Length: | 173 |
Molecular Weight: | 19909.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
Substrate |
protein |
---|
1: MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSG
61: ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH NERQDDHGYI SREFHRRYRL
121: PSNVDQSALS CSLSADGMLT FCGPKIQTGL DATHAERAIP VSREEKPTSA PSS