8.A.174.1.1
Cytochrome c oxidase assembly protein, COX15, of 410 aas and 7 or 8 TMSs in a 1 + 3 + 1 + 3 TMS arrangement. A variant in the COX15 gene causes a fatal infantile cardioencephalomyopathy (Galvão de Oliveira et al. 2021). This protein is homologous but distantly related to a protein annotated as heme A synthase, CtaA (TC# 3.A.4.4.1; P12946).
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| Accession Number: | Q7KZN9 |
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| Protein Name: | Cytochrome c oxidase assembly protein COX15 homolog |
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| Length: | 410 |
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| Molecular Weight: | 46030.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MQRLLFPPLR ALKGRQYLPL LAPRAAPRAQ CDCIRRPLRP GQYSTISEVA LQSGRGTVSL
61: PSKAAERVVG RWLLVCSGTV AGAVILGGVT RLTESGLSMV DWHLIKEMKP PTSQEEWEAE
121: FQRYQQFPEF KILNHDMTLT EFKFIWYMEY SHRMWGRLVG LVYILPAAYF WRKGWLSRGM
181: KGRVLALCGL VCFQGLLGWY MVKSGLEEKS DSHDIPRVSQ YRLAAHLGSA LVLYCASLWT
241: SLSLLLPPHK LPETHQLLQL RRFAHGTAGL VFLTALSGAF VAGLDAGLVY NSFPKMGESW
301: IPEDLFTFSP ILRNVFENPT MVQFDHRILG ITSVTAITVL YFLSRRIPLP RRTKMAAVTL
361: LALAYTQVGL GISTLLMYVP TPLAATHQSG SLALLTGALW LMNELRRVPK