8.A.183.2.1
Lipid droplet-regulated VLDL assembly factor, AUP1 of 410 aas and possibly as many as 4 TMSs at residue positions 20 - 60 ( 2 TMSs) + 1 at residue 200 + 1 at about residue 340. It plays a role in the translocation of terminally misfolded proteins from
the endoplasmic reticulum (ER) lumen to the cytoplasm and their degradation
by a proteasome. It also plays a role in lipid droplet formation and induces lipid droplet clustering (Klemm et al. 2011). It also regulates the ER-associated degradation and polyubiquitination of NKCC2 (Frachon et al. 2024).
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| Accession Number: | Q9Y679 |
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| Protein Name: | Lipid droplet-regulating VLDL assembly factor AUP1 |
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| Length: | 410 |
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| Molecular Weight: | 45787.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 |
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| Substrate |
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1: MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV
61: LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP
121: SFVCWSRGFM EMNGRGELVE SLKRFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS
181: IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLRPVH RQLGEANEEF
241: ALRVQQLVAK ELGQTGTRLT PADKAEHMKR QRHPRLRPQS AQSSFPPSPG PSPDVQLATL
301: AQRVKEVLPH VPLGVIQRDL AKTGCVDLTI TNLLEGAVAF MPEDITKGTQ SLPTASASKF
361: PSSGPVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FTERRAQEAD