| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.196.1.1 | Tapasin chaparone, isoform 1 precursor, of 448 aas and 2 TMSs, one N-terminal and one C-terminal. It is involved in the association of MHC class I with the transporter associated with antigen processing (TAP, TC# 3.A.1.209.1) and in the assembly of MHC class I with peptide (peptide loading). Tapasin is required for efficient peptide binding to the transporter associated with antigen processing, TAP (Li et al. 2000). TAP and the MHC I-specific chaperone, tapasin, are essential for the assembly of the peptide-loading complex (PLC) and for efficient MHC I antigen presentation (Blees et al. 2015). Tapasin forms an inter-subunit salt bridge with TAP1-TAP2 and thus, may interact directly with TAP (Blees et al. 2015). | Eukaryota |
Metazoa, Chordata | Tapasin of Homo sapiens |
|
8.A.196.1.2 | Tapasin-related protein, TAPBPL, of 468 aas and 2 TMSs, N- and C-terminal. It is a component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). | Eukaryota |
Metazoa, Chordata | TAPBL of Homo sapiens |
|
8.A.196.1.3 | Tapasin-related protein-like, TRL, isoform X1 of 476 aas and 2 TMSs, N- and C-terminal. | Eukaryota |
Metazoa, Chordata | TRL-X1 of Apteryx rowi (Okarito brown kiwi) |
|
8.A.196.1.4 | Ribosome-binding protein 1-like isoform X14 of 670 aas and 1 (possibly 2) TMS(s) at about residue 240. | Eukaryota |
Metazoa, Chordata | Ribosome-binding protein of Chiloscyllium plagiosum (whitespotted bambooshark) |
|
8.A.196.1.5 | Uncharacterized protein of 870 aas and 2 TMSs, one N-terminal, and one at ~ residue 270. | Eukaryota |
Metazoa, Chordata | UP of Xenopus tropicalis (tropical clawed frog) |