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| Accession Number: | Q08289 |
| Protein Name: | CACNB2 aka CACNLB2 aka MYSB |
| Length: | 660 |
| Molecular Weight: | 73581.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Peripheral membrane protein2 / Cytoplasmic side3 |
| Substrate | |
Cross database links:
| DIP: | DIP-46117N DIP-46117N |
|---|---|
| RefSeq: | NP_000715.2 NP_963864.1 NP_963865.2 NP_963884.2 NP_963887.2 NP_963890.2 NP_963891.1 |
| Entrez Gene ID: | 783 |
| Pfam: | PF00625 PF12052 |
| OMIM: |
600003 gene 611876 phenotype |
| KEGG: | hsa:783 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0042383
C:sarcolemma
GO:0005891
C:voltage-gated calcium channel complex
GO:0005515
F:protein binding
GO:0005245
F:voltage-gated calcium channel activity
GO:0006816
P:calcium ion transport
GO:0007528
P:neuromuscular junction development
GO:0007411
P:axon guidance
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References (13)[1] “Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.” Rosenfeld M.R.et.al. 8494331 [2] “Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.” Taviaux S.et.al. 9254841 [3] “The DNA sequence and comparative analysis of human chromosome 10.” Deloukas P.et.al. 15164054 [4] “Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.” Yada H.et.al. 17525370 [5] “The consensus coding sequences of human breast and colorectal cancers.” Sjoeblom T.et.al. 16959974 [6] “Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.” Antzelevitch C.et.al. 17224476 [7] “Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.” Rosenfeld M.R.et.al. 8494331 [8] “Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.” Taviaux S.et.al. 9254841 [9] “The DNA sequence and comparative analysis of human chromosome 10.” Deloukas P.et.al. 15164054 [10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [11] “Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.” Yada H.et.al. 17525370 [12] “The consensus coding sequences of human breast and colorectal cancers.” Sjoeblom T.et.al. 16959974 [13] “Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.” Antzelevitch C.et.al. 17224476
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MVQRDMSKSP PTAAAAVAQE IQMELLENVA PAGALGAAAQ SYGKGARRKN RFKGSDGSTS 61: SDTTSNSFVR QGSADSYTSR PSDSDVSLEE DREAVRREAE RQAQAQLEKA KTKPVAFAVR 121: TNVSYSAAHE DDVPVPGMAI SFEAKDFLHV KEKFNNDWWI GRLVKEGCEI GFIPSPVKLE 181: NMRLQHEQRA KQGKFYSSKS GGNSSSSLGD IVPSSRKSTP PSSAIDIDAT GLDAEENDIP 241: ANHRSPKPSA NSVTSPHSKE KRMPFFKKTE HTPPYDVVPS MRPVVLVGPS LKGYEVTDMM 301: QKALFDFLKH RFEGRISITR VTADISLAKR SVLNNPSKHA IIERSNTRSS LAEVQSEIER 361: IFELARTLQL VVLDADTINH PAQLSKTSLA PIIVYVKISS PKVLQRLIKS RGKSQAKHLN 421: VQMVAADKLA QCPPELFDVI LDENQLEDAC EHLADYLEAY WKATHPPSSS LPNPLLSRTL 481: ATSSLPLSPT LASNSQGSQG DQRTDRSAPI RSASQAEEEP SVEPVKKSQH RSSSSAPHHN 541: HRSGTSRGLS RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH 601: RHRESRHRSR DVDREQDHNE CNKQRSRHKS KDRYCEKDGE VISKKRNEAG EWNRDVYIRQ