8.A.238. The Cell Permeabiity Peptide (CPP) Family
Some members of this family directly, or indirectly, regulate GLUT2 gene expression and beta-cell function. They appear to play a role in cell signaling in mature and developing nerve terminals. They may also function as regulators of vesicle transport, through interactions with the JNK-signaling components and motor proteins. They function as anti-apoptotic proteins. Their levels seem to influence the beta-cell death or survival response (Harders et al. 2024).
References associated with 8.A.238 family:
Akama, K.T., L.I. Thompson, T.A. Milner, and B.S. McEwen. (2013). Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines. J. Biol. Chem. 288: 6438-6450. 23300088
Harders, R.H., T.H. Morthorst, L.E. Landgrebe, A.D. Lande, M.S. Fuglsang, S.B. Mortensen, V. Feteira-Montero, H.H. Jensen, J.B. Wesseltoft, and A. Olsen. (2024). CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans. G3 (Bethesda) 14:. 38696649
Liu, Q.A. and M.O. Hengartner. (1999). Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Curr. Biol. 9: 1347-1350. 10574771
Noritake, J., Y. Fukata, T. Iwanaga, N. Hosomi, R. Tsutsumi, N. Matsuda, H. Tani, H. Iwanari, Y. Mochizuki, T. Kodama, Y. Matsuura, D.S. Bredt, T. Hamakubo, and M. Fukata. (2009). Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J. Cell Biol. 186: 147-160. 19596852
Smits, E., W. Van Criekinge, G. Plaetinck, and T. Bogaert. (1999). The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells. Curr. Biol. 9: 1351-1354. 10574763