8.A.240. The Metastasis-associated in Colon Cancer protein 1 (MACC1) Family
The MACC1 protein acts as a transcription activator for MET and as a key regulator of HGF-MET signaling while promoting cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo (Stein et al. 2009). MACC1 regulates Cu homeostasis mediated by the cytochrome oxidase assembly protein, COX19 (see TC# 8.A.239) (Gao et al. 2024).
References associated with 8.A.240 family:
Gao, S., H. Zhang, X. Zhang, J. Wang, W. Bai, and B. Jiang. (2024). COX19 Is a New Target of MACC1 and Promotes Colorectal Cancer Progression by Regulating Copper Transport in Mitochondria. J Nutr 154: 381-394. 38141772
Stein, U., W. Walther, F. Arlt, H. Schwabe, J. Smith, I. Fichtner, W. Birchmeier, and P.M. Schlag. (2009). MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat. Med. 15: 59-67. 19098908