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View Proteins belonging to: The Vascular Endothelial Growth Factor (VEGF) Family

8.A.245.  The Vascular Endothelial Growth Factor (VEGF) Family 

Members participate in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (Katsman et al. 2022).  It is also involved in protecting cells from hypoxia-mediated cell death.  It is active in angiogenesis, vasculogenesis and endothelial cell growth (Lee et al. 2021), and induces permeabilization of blood vessels, while preventing the downregulation of KCC2 induced by axotomy in extraocular motoneurons (Capilla-López et al. 2024).  The potassium-chloride cotransporter KCC2 is the main extruder of Cl- in neurons. It plays a fundamental role in the activity of the inhibitory neurotransmitters (GABA and glycine) since low levels of KCC2 promote intracellular Cl- accumulation, leading to the depolarizing activity of GABA and glycine. (See 2.A.30.1.14 and 18 for KCC2 descriptions.)

View Proteins belonging to: The Vascular Endothelial Growth Factor (VEGF) Family

References associated with 8.A.245 family:

Capilla-López, J., R.G. Hernández, G. Carrero-Rojas, P.M. Calvo, F.J. Alvarez, R.R. de la Cruz, and A.M. Pastor. (2024). VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons. Int J Mol Sci 25:. 39337430
Katsman, M., A. Azriel, G. Horev, Y. Reizel, and B.Z. Levi. (2022). N-VEGF, the Autoregulatory Arm of VEGF-A. Cells 11:. 35455969
Lee, J.W., J. Hur, Y.W. Kwon, C.W. Chae, J.I. Choi, I. Hwang, J.Y. Yun, J.A. Kang, Y.E. Choi, Y.H. Kim, S.E. Lee, C. Lee, D.H. Jo, H. Seok, B.S. Cho, S.H. Baek, and H.S. Kim. (2021). KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state. J Hematol Oncol 14: 148. 34530889
Leppänen, V.M., M. Jeltsch, A. Anisimov, D. Tvorogov, K. Aho, N. Kalkkinen, P. Toivanen, S. Ylä-Herttuala, K. Ballmer-Hofer, and K. Alitalo. (2011). Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood 117: 1507-1515. 21148085