TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
8.A.33.1.1 | The epidermal (psoriasis-associated) fatty acid binding protein, FABP (Wang et al., 2007; Schwenk et al. 2010). It is a skeletal muscle protein, involved in fatty acid transport, that influences fatty acid oxidation rates (Maunder et al. 2023). Upregulating FcRn inhibits ferroptosis to alleviate lesional skin in psoriasis (Qian et al. 2024). The neonatal Fc receptor (FcRn) plays a crucial role in the development of autoimmune diseases (Schwenk et al. 2010). It is a skeletal muscle protein, involved in fatty acid transport, that influences fatty acid oxidation rates (Maunder et al. 2023). Upregulating FcRn inhibits ferroptosis to alleviate lesional skin in psoriasis (Qian et al. 2024). The neonatal Fc receptor (FcRn) plays a crucial role in the development of autoimmune diseases (Qian et al. 2024). | Eukaryota |
Metazoa, Chordata | FABP of Homo sapiens (Q01469) |
8.A.33.1.2 | The fatty acid binding protein, FABP1 (Schwenk et al. 2010). | Eukaryota |
Metazoa, Chordata | FABP1 of Homo sapiens (Q05CP7) |
8.A.33.1.3 | Retinol-binding protein 2 (Cellular retinol-binding protein II) (CRBP-II) of 134 aas and 0 TMSs. It may play a role in rretinol and retinyl-palmitate transport (Reboul 2013). | Eukaryota |
Metazoa, Chordata | CRBP-II of Homo sapiens |
8.A.33.1.4 | Fatty acid binding protein 10-A of 134 aas and 0 TMSs | Eukaryota |
Metazoa, Chordata | FABP 10-A of Danio rerio (Zebrafish) (Brachydanio rerio) |
8.A.33.1.5 | Cellular retinoic acid binding protein 2, CRABP2 or CRABPII, of 138 aas and possibly 2 TMSs, N- and C-terminal. It is a microbial rhodopsin mimic, a small soluble protein that photoisomerizes all- trans to 13- cis retinal followed by thermal relaxation to the all- trans isomer, mimicking the bacteriorhodopsin photocycle. The key element for selective isomerization is a tuned steric interaction between the chromophore and protein, similar to that seen in the microbial rhodopsins (Ghanbarpour et al. 2019). | Eukaryota |
Metazoa, Chordata | CRABP2 of Capra hircus (goat) |