8.A.58.2.13
Synapse differentiation-inducing gene protein 1, SynDIG1 or TMEM90B, of 258 aas and 2 TMSs. Regulates AMPA receptor content at nascent synapses, and plays a role in postsynaptic development and maturation (Kalashnikova et al. 2010). Palmitoylation of SynDIG1 is regulated by neuronal activity, and plays a
critical role in regulating its stability, subcellular localization and function (Kaur et al. 2016). SynDIG1 regulates the maturation of excitatory synapse structure and function (Chenaux et al. 2016; Kirk et al. 2016). SynDIG4 and PRRT1 act as typical AMPAR auxiliary proteins, while PRRT2 functions at presynaptic sites to regulate synaptic vesicle dynamics and is the causative gene for neurological paroxysmal disorders in humans (Dίaz 2021).
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| Accession Number: | Q9H7V2 |
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| Protein Name: | Synapse differentiation-inducing gene protein 1 |
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| Length: | 258 |
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| Molecular Weight: | 28551.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MDGIIEQKSM LVHSKISDAG KRNGLINTRN LMAESRDGLV SVYPAPQYQS HRVGASTVPA
61: SLDSSRSEPM QQLLDPNTLQ QSVESRYRPN IILYSEGVLR SWGDGVAADC CETTFIEDRS
121: PTKDSLEYPD GKFIDLSADD IKIHTLSYDV EEEEEFQELE SDYSSDTESE DNFLMMPPRD
181: HLGLSVFSML CCFWPLGIAA FYLSHETNKA VAKGDLHQAS TSSRRALFLA VLSITIGTGV
241: YVGVAVALIA YLSKNNHL