8.A.6.1.1
Cold-sensitive fermentation (CSF1) protein of 2985 aas. It is a tube-forming lipid transport protein which provides
phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor
synthesis in the endoplasmic reticulum (Toulmay et al. 2022). It is required for the glucose and other nutrients uptake at low temperature (Tokai et al. 2000).
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| Accession Number: | Q12150 |
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| Protein Name: | CSF1 aka YLR087C aka L9449.14 |
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| Length: | 2958 |
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| Molecular Weight: | 338258.00 |
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| Species: | Saccharomyces cerevisiae (Baker's yeast) [4932] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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| RefSeq: |
NP_013188.1
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| Entrez Gene ID: |
850776
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| KEGG: |
sce:YLR087C
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[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.” Johnston M. et.al. 9169871
[2] “Cloning and characterization of the CSF1 gene of Saccharomyces cerevisiae, which is required for nutrient uptake at low temperature.” Tokai M. et.al. 10781556
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1: MEAISQLRGV PLTHQKDFSW VFLVDWILTV VVCLTMIFYM GRIYAYLVSF ILEWLLWKRA
61: KIKINVETLR VSLLGGRIHF KNLSVIHKDY TISVLEGSLT WKYWLLNCRK AELIENNKSS
121: SGKKAKLPCK ISVECEGLEI FIYNRTVAYD NVINLLSKDE RDKFEKYLNE HSFPEPFSDG
181: SSADKLDEDL SESAYTTNSD ASIVNDRDYQ ETDIGKHPKL LMFLPIELKF SRGSLLLGNK
241: FTPSVMILSY ESGKGIIDVL PPKERLDLYR NKTQMEFKNF EISIKQNIGY DDAIGLKFKI
301: DRGKVSKLWK TFVRVFQIVT KPVVPKKTKK SAGTSDDNFY HKWKGLSLYK ASAGDAKASD
361: LDDVEFDLTN HEYAKFTSIL KCPKVTIAYD VDVPGVVPHG AHPTIPDIDG PDVGNNGAPP
421: DFALDVQIHG GSICYGPWAQ RQVSHLQRVL SPVVSRTAKP IKKLPPGSRR IYTLFRMNIS
481: IMEDTTWRIP TRESSKDPEF LKHYKETNEE YRPFGWMDLR FCKDTYANFN ISVCPTVQGF
541: QNNFHVHFLE TEIRSSVNHD ILLKSKVFDI DGDIGYPLGW NSKAIWIINM KSEQLEAFLL
601: REHITLVADT LSDFSAGDPT PYELFRPFVY KVNWEMEGYS IYLNVNDHNI VNNPLDFNEN
661: CYLSLHGDKL SIDVTVPRES ILGTYTDMSY EISTPMFRMM LNTPPWNTLN EFMKHKEVGR
721: AYDFTIKGSY LLYSELDIDN VDTLVIECNS KSTVLHCYGF VMRYLTNVKM NYFGEFFNFV
781: TSEEYTGVLG AREVGDVTTK SSVADLASTV DSGYQNSSLK NESEDKGPMK RSDLKRTTNE
841: TDIWFTFSVW DGALILPETI YSFDPCIALH FAELVVDFRS CNYYMDIMAV LNGTSIKRHV
901: SKQINEVFDF IRRNNGADEQ EHGLLSDLTI HGHRMYGLPP TEPTYFCQWD INLGDLCIDS
961: DIEFIKGFFN SFYKIGFGYN DLENILLYDT ETINDMTSLT VHVEKIRIGL KDPVMKSQSV
1021: ISAESILFTL IDFENEKYSQ RIDVKIPKLT ISLNCVMGDG VDTSFLKFET KLRFTNFEQY
1081: KDIDKKRSEQ RRYITIHDSP YHRCPFLLPL FYQDSDTYQN LYGAIAPSSS IPTLPLPTLP
1141: DTIDYIIEDI VGEYATLLET TNPFKNIFAE TPSTMEPSRA SFSEDDNDEE ADPSSFKPVA
1201: FTEDRNHERD NYVVDVSYIL LDVDPLLFIF AKSLLEQLYS ENMVQVLDDI EIGIVKRLSN
1261: LQEGITSISN IDIHIAYLNL IWQETGEEGF ELYLDRIDYQ MSEKSLEKNR TNKLLEVAAL
1321: AKVKTVRVTV NQKKNPDLSE DRPPALSLGI EGFEVWSSTE DRQVNSLNLT SSDITIDESQ
1381: MEWLFEYCSD QGNLIQEVCT SFNSIQNTRS NSKTELISKL TAASEYYQIS HDPYVITKPA
1441: FIMRLSKGHV RENRSWKIIT RLRHILTYLP DDWQSNIDEV LKEKKYTSAK DAKNIFMSVF
1501: STWRNWEFSD VARSYIYGKL FTAENEKHKQ NLIKKLLKCT MGSFYLTVYG EGYEVEHNFV
1561: VADANLVVDL TPPVTSLPSN REETIEITGR VGSVKGKFSD RLLKLQDLIP LIAAVGEDDK
1621: SDPKKELSKQ FKMNTVLLVD KSELQLVMDQ TKLMSRTVGG RVSLLWENLK DSTSQAGSLV
1681: IFSQKSEVWL KHTSVILGEA QLRDFSVLAT TEAWSHKPTI LINNQCADLH FRAMSSTEQL
1741: VTAITEIRES LMMIKERIKF KPKSKKKSQF VDQKINTVLS CYFSNVSSEV MPLSPFYIRH
1801: EAKQLDIYFN KFGSNEILLS IWDTDFFMTS HQTKEQYLRF SFGDIEIKGG ISREGYSLIN
1861: VDISISMIKL TFSEPRRIVN SFLQDEKLAS QGINLLYSLK PLFFSSNLPK KEKQAPSIMI
1921: NWTLDTSITY FGVLVPVAST YFVFELHMLL LSLTNTNNGM LPEETKVTGQ FSIENILFLI
1981: KERSLPIGLS KLLDFSIKVS TLQRTVDTEQ SFQVESSHFR VCLSPDSLLR LMWGAHKLLD
2041: LSHYYSRRHA PNIWNTKMFT GKSDKSKEMP INFRSIHILS YKFCIGWIFQ YGAGSNPGLM
2101: LGYNRLFSAY EKDFGKFTVV DAFFSVANGN TSSTFFSEGN EKDKYNRSFL PNMQISYWFK
2161: RCGELKDWFF RFHGEALDVN FVPSFMDVIE STLQSMRAFQ ELKKNILDVS ESLRAENDNS
2221: YASTSVESAS SSLAPFLDNI RSVNSNFKYD GGVFRVYTYE DIETKSEPSF EIKSPVVTIN
2281: CTYKHDEDKV KPHKFRTLIT VDPTHNTLYA GCAPLLMEFS ESLQKMIKKH STDEKPNFTK
2341: PSSQNVDYKR LLDQFDVAVK LTSAKQQLSL SCEPKAKVQA DVGFESFLFS MATNEFDSEQ
2401: PLEFSLTLEH TKASIKHIFS REVSTSFEVG FMDLTLLFTH PDVISMYGTG LVSDLSVFFN
2461: VKQLQNLYLF LDIWRFSSIL HTRPVQRTVN KEIEMSSLTS TNYADAGTEI PWCFTLIFTN
2521: VSGDVDLGPS LGMISLRTQR TWLATDHYNE KRQLLHAFTD GISLTSEGRL SGLFEVANAS
2581: WLSEVKWPPE KSKNTHPLVS TSLNIDDIAV KAAFDYHMFL IGTISNIHFH LHNEKDAKGV
2641: LPDLLQVSFS SDEIILSSTA LVVANILDIY NTIVRMRQDN KISYMETLRD SNPGESRQPI
2701: LYKDILRSLK LLRTDLSVNI SSSKVQISPI SLFDVEVLVI RIDKVSIRSE THSGKKLKTD
2761: LQLQVLDVSA ALSTSKEELD EEVGASIAID DYMHYASKIV GGTIIDIPKL AVHMTTLQEE
2821: KTNNLEYLFA CSFSDKISVR WNLGPVDFIK EMWTTHVKAL AVRRSQVANI SFGQTEEELE
2881: ESIKKEEAAS KFNYIALEEP QIEVPQIRDL GDATPPMEWF GVNRKKFPKF THQTAVIPVQ
2941: KLVYLAEKQY VKILDDTH