8.A.6.1.2
Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein, Lpd-1, of 4018 aas and at least one N-terminal TMS, but several additional potential TMSs. It is a tube-forming lipid transport protein which provides
phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor
synthesis in the endoplasmic reticulum. It also plays a role in
endosomal trafficking and endosome recycling, and is involved in the actin
cytoskeleton and cilia structural dynamics (Kane et al. 2019). It acts as regulator of phagocytosis (Jeng et al. 2019).
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| Accession Number: | NP_001300464 |
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| Protein Name: | NP_001300464.1 Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans] |
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| Length: | 4019 |
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| Molecular Weight: | |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MSDFDIQIKI DDAQLDLKGV SFWVTASVVT LFLAWSTFVV LFFSRVSALF FTFVIDKYLR
61: LSKNGIHFKI GGISISGLHA GKIMFRNVIY DNGDMTIKVN DGHLLFKYWK SVEHRHLNLS
121: TKRASRLHLV LNGLHVNIYN NLTKYTEIAR IRRFDWFFEN TNMNDARRPQ TKPPDTSPPS
181: SVWENMWNLL GIVHIEVSAG CILVGNKFLP YALWTRFENL NSKTSVTESA NDRALLTFEG
241: ETENVAVSLI KNEQFDFTAK DKDPPRTMGN DGCPLLQSAS LEFVYKQDLL GYVTDDEPQS
301: ITLKLPLWSS EWRFGNNTVL SYGPWAEQQR FLIYSFFYPP DFQNSTATAM PTRGKKRIHV
361: KHDVKIILTK ETCMDIWFMR GEQLESIRTR CGPLSSLDMS ILWITTEKGF YWNMKAEFLN
421: FEATTSLIFT KLFSCKKFNV DGSFVYPLTW NGEQTWTIDY AFTKANAWFV WDHKRLFTDL
481: INDWIGDDPS DISKFVPFRV HNRMKVVDGF EVIMLLNESN WVDTADMNAE NVEVAIVGEK
541: LSFECELPFV DFLPQTQMVK YEMRGEKSVA MRAKFPPDSA TAPIRAALSR LARCNSYAPP
601: SKHGTHSLDT DVWFELWRTE LVKMDFDHHY RPLIVKSNIP SDIPFSILSD YLPPPANHPW
661: DLEPDYLGVD ILIEGSDVKF TGLLVKLLFE LKNNYFGWYD SMTSVDDEKI DDPIKLKASF
721: DKTNANGMKP VEYFRTMNVD VTVRVCNVRA EMLLYSPAID EGAEPEKVPV VFVEEVAVEV
781: KKTKTQALIQ VGVSPACAYL DKSSQGSGPG CITLSGFQFR GHAMYSAKEV AWNMGLVEYG
841: WIMEILVGDI AGTLDFPAHA HVLHQIMESL LMFVISPDDA TKVPDRMQFC QHGQLIKACS
901: IAGKKTNEIL GPCKTEEQMK YRQIRISVDS VNLTFVEEKT ILQISADPVR VTICNAHESR
961: FTEHVCIRVP GISIRQAVRI KEKPENIWIE GANAAIEGVS LDIELPTPKS ASPTIGKERL
1021: EFVRMHDADT KRLHFLWADH SVWGCACFGN TCFFGDVDEI GSTFMETLTK KKFFVPGIER
1081: NPEKQPQVMQ SVILKNKPIL SNQPHMFYKK PKNADVVITI RKESTGDTES FHSARSQQSP
1141: GLRILQSMEM SSSYATFVDN VRVELPSAIT VPQFGEPGAI LEWCQAHQAT RIINDVNTSG
1201: VNEVRFLSKP KKSQDIEYNT SRDTLGKRRL AINGVAATSL DLFVTPIGIE AFERLVTAAS
1261: HSVPAINPCI LVHMCYRDCV LKKHRQPLTE SLFADEDNDS EPISEVDITV DLPRVSIGLF
1321: QCGVKKNIVK SNHTDHITAN MGLLLIDRAF IQSKLIPAES VSQDFSADTS NLSSTLYQLN
1381: GSAITVQLLQ LTNRDAPDFG SSGTATTPNN WEHCAISRRM NNLEPRVMMD FNVSDTLIIL
1441: ERRPIILLLP DKSTTAITPI HSPANAPTPT AMNRTPTLTL TPSAGAGGGE RAEPMRKKKK
1501: MICEHYLKAD IGSVTTALVM ARPQELTAGD EFPIYEALAP VMVSWLSVVE NFLRTVDKFI
1561: HTVECWKSVA MAKVLKLALD STDEKVVVKV GKNRMGRTRV LSAHQASCPS CILLKTLFRW
1621: FAYAGNAPGA INHRLDIRPE FEIEETRKTA LMALLSHWQS DVGKELKLVS YEDAHRFKVT
1681: RPDEAAIVAL TKSKRLKRKM LEKKESSKKE TRVVMEVKPE QPKAKRGRMS PAPLLKKLRK
1741: KAGDDDFDDD SMKFLSDVEM QEFNTLPLYE DYEDDEMLEN LDSEPKIDDK VDLYTWMRNA
1801: QRESTLRRRK LAGGAEGSVK DDLNLKGYIN PMDIQQKAYY YNIYRWAQLQ WTSLDGIEKD
1861: HWHLDYSVTL REVDVRMMAK SIKNSSDHLR QYITPAQQKV MQVRNAAVNG GMVWKMERDE
1921: RRKIPLHGQW NISYSGNVEG IRFLIGMATV SLGKELSLVL RVAMEAKNEL RMHSTAESTP
1981: RNEVKVFKPV VPNQYDLAVE WDEKVLDMTR DYEKHMQRMR TNKEDVVEKV KVMVNGSAMV
2041: SSIVLESVLN DLYVSVTISQ IVLAHSKNPM PDIPVVVHAV TLSTTPTAAA AEDKKTATLT
2101: KKSVSSTFKI DDLTVSLTKM KLTLSEADSS NKKSDILRCT LNSSSFNVHT NLKTLTSAKE
2161: SNRPKNNLIN SNIATTATLR LGALEGTMPM AAYSLHDVVM RHGKELEQQL NRLAAQPAST
2221: PLSSSTPFPS AEQSLLAKVA DMKTAPEPVV ITQAEFKPLT TLPATAAHVQ DAKGQIVRRV
2281: PVAVVSFSIE LTSIEMNIQL LPSLQAKYRI NRATSNGITG VQANWSILLD EHFFEFCVTG
2341: QGGKTETFRL QLPSVTSDGL YQAEQGVSSQ KPSTDKKLIY REGGSLQMTV VLGRVNHIFT
2401: TELLNQLMFA EHSFRTELTA LINRIRSSSF ASTNSSRSAQ STNDRVNSTA NLKLLLPVQT
2461: TSTPVHIEKP PLLFSIKIQT KEIPRKDEKT DKDAKTPKAS GASGNLDQSQ HPSHSTHVKS
2521: TPWLQLTAAT PTQTAVRLTV DSLEGELTNK WVVKEEGSKE RIYGNAVIHF NAKLGQLIKP
2581: VPTGDSVAAT DVTDLQEFAT FMTQVRVENK ERNMFNSSYS YHISLNRPIF LVKAAAIDKA
2641: ILLWLNYKNT YDYWRNEREK VVQEKTTTKL SNAGMFSPTQ IAEDADMNLS LAINNGMYMC
2701: MPLYSHDVTE GMPALVLSLQ KSNLSVLVKK ELTCKASFNG FKCSFVDDFD EQALTQSFLD
2761: ATHSDQSNCI FFPEGTYQLC SKAEATKGPA KWVLSVSAEM QGVEIDLDTR IGKLAKLLVN
2821: TFSMIRTDDD DDMSFWGDEG ELDSDEEKVE GASELKKLKA EEKVPWMENK MHEHSRAVFE
2881: LAARGVSNKL IEAEKHKLRQ YELIRFKAFR RNVVEKLKKG TTASRQHTET PPPQPRPDTT
2941: SRRNSRTTST SQKNSEDLTT PGDIETVNFN LDVKVNITSG TCTLRTQKKE GANQLALPGI
3001: LKRLNLGTKD IKAMFEPQII TTTTFSIPSV EIKAYHVSDP SNRSTDEFCK DKREKISKGL
3061: AKDADKLHRD LHNKSRFGNT YINGGGGPKT STVPPPPKRG CFYIFVGLAS MPSETVVTPH
3121: LATYFEQVLE PLPPSAVFQS QNNTREASVP DDGKGDANNE VHNIMAMDTA AFPIDFVFYL
3181: DVQSSTIRFD GKQPTSRSQT QADCLLTLPR LTLELTSKRT RDNIDNYVGG IHISGQFKGF
3241: MLKIYNPLEL EPDSSRALQL SLDLLSFVIS RNKNSSTEPD NRVRFVFSSQ ISKASFEYNF
3301: RRLGELIQFP KPWYRAAIAR RVFFGDQAAP RQKDDASDIT GTTRSRLPTD PKSLQPPAAS
3361: TASTGSGSFV PHQRKPWTAL VLAAIQWNEF EVTAFMSNTM GKTTWKATKG LVWGDAKLNS
3421: LNERDVSISF VLGSSELCAR DGAISGTIML NNLKVSADHS LSADVKRVPV NKAKIRLEWI
3481: TANIEWMSRR VLIAKWCGPS FKVNDYYKGL KEGDHFALSE LGMNVQASWK DLQVVITKST
3541: VDDVAAIVNR LISFIDEQLK NSRILLGNLS ASTNLKKQAQ ALIESRKPTT HFWEKVLDYM
3601: SEMQMNEQLM GLMEREGAKV GGHIELKAGG ISLVMMKGDM NADTWAVFHL RDACILFDPE
3661: ARMDFLDNSS QQKIGILLKQ TFCLQLGSRH GNQTENRANV CRVQTRFNNS RHLQKAEDIL
3721: EFFIGDVMKI IGSADHSEKK KLKEVEVIQS PISENENTAK SPTSTFSRFR SPGTSKTKES
3781: GPATNHNVME LFQFPGLEAK MSSQQLNGVD DGDKYESVFQ MPMDVLTTFV CDFFSEVAIE
3841: TNFNAQVSFL PELLKSYLKE SHSGTSSSHS TNSSPAVSSS KESVVSETSK DPRIFTCQEW
3901: KVEPRVRFID RIKWTPPVLD DILKKLQIFD HRNTIPKVIQ RAVLDPLDAT LAASVIATLQ
3961: IVDNKKTIQK FKKSRTDSMA PTPKRRDSRR SSEEVSVSID IPDIITDISD ASFRPKHN