8.A.6.1.3
Bridge-like lipid transfer protein family member 1, Bltp1, of 5005 aas with one N-terminal TMS plus possibly additional TMSs elsewhere. It is a tube-forming lipid transport protein which provides
phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor
synthesis in the endoplasmic reticulum, and it plays a role in
endosomal trafficking and endosome recycling. It may also be involved in the actin
cytoskeleton and cilia structural dynamics (Kane et al. 2019) while also acting as a regulator of phagocytosis (Jeng et al. 2019).
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| Accession Number: | Q2LD37 |
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| Protein Name: | Bridge-like lipid transfer protein family member 1 |
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| Length: | 5005 |
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| Molecular Weight: | 555482.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass membrane protein2 |
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| Substrate |
lipid, phosphatidylethanolamine |
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1: MDQRKNESIV PSITQLEDFL TEHNSNVVWL LVATILSCGW IIYLTYYNSR NVGLILTLVL
61: NRLYKHGYIH IGSFSFSVLS GKVMVREIYY ITEDMSIRIQ DGFIIFRWWK MYNPKQKQHD
121: PKAETRLYIT VNDFEFHVYN RSDLYGRLQE LFGLEPTIIP PKKDDDKTRE IGRTRTQSKI
181: ERVKVKTESQ DPTSSWRSLI PVIKVNVSTG RLAFGNHYQP QTLCINFDDA FLTYTTKPPS
241: SHLDQFMHIV KGKLENVRVM LVPSPRYVGL QNDEPPRLMG EGFVVMQSND VDIYYYMDEP
301: GLVPEETEEN IEGEMSSEDC KLQDLPPCWG LDIVCGKGTD FNYGPWADRQ RDCLWKFFFP
361: PDYQVLKVSE IAQPGRPRQI LAFELRMNII ADATIDLLFT KNRETNAVHV NVGAGSYLEI
421: NIPMTVEENG YTPAIKGQLL HVDATTSMQY RTLLEAEMLA FHINASYPRI WNMPQTWQCE
481: LEVYKATYHF IFAQKNFFTD LIQDWSSDSP PDIFSFVPYT WNFKIMFHQF EMIWAANQHN
541: WIDCSTKQQE NVYLAACGET LNIDFSLPFT DFVPATCNTK FSLRGEDVDL HLFLPDCHPS
601: KYSLFMLVKN CHPNKMIHDT GIPAECQSGQ KTVKPKWRNV TQEKSGWVEC WTVPSVMLTI
661: DYTWHPIYPQ KADEQLKQSL SEMEETMLSV LRPSQKTSDR VVSSPSTSSR PPIDPSELPP
721: DKLHVEMELS PDSQITLYGP LLNAFLCIKE NYFGEDDMYM DFEEVISSPV LSLSTSSSSG
781: WTAVGMENDK KENEGSAKSI HPLALRPWDI TVLVNLYKVH GRLPVHGTTD GPECPTAFLE
841: RLCFEMKKGF RETMLQLILS PLNVFVSDNY QQRPPVDEVL REGHINLSGL QLRAHAMFSA
901: EGLPLGSDSL EYAWLIDVQA GSLTAKVTAP QLACLLEWGQ TFVFHVVCRE YELERPKSVI
961: ICQHGIDRRF CESKLSCIPG PCPTSDDLKY TMIRLAVDGA DIYIVEHGCA TNIKMGAIRV
1021: ANCNLHNQSV GEGISAAIQD FQVRQYIEQL NNCRIGLQPA VLRRAYWLEA GSANLGLITV
1081: DIALAADHHS KHEAQRHFLE THDARTKRLW FLWPDDILKN KRCRNKCGCL GGCRFFGGTV
1141: TGLDFFKLEE LTPSSSSAFS STSAESDMYY GQSLLQPGEW IITKEIPKII DGNVNGMKRK
1201: EWENKSVGIE VERKTQHLSL QVPLRSHSSS SSSEENSSSS AAQPLLAGEK ESPSSVADDH
1261: LVQKEFLHGT KRDDGQASIP TEISGNSPVS PNTQDKSVGQ SPLRSPLKRQ ASVCSTRLGS
1321: TKSLTAAFYG DKQPVTVGVQ FSSDVSRSDE NVLDSPKQRR SFGSFPYTPS ADSNSFHQYR
1381: SMDSSMSMAD SEAYFSAAEE FEPISSDEGP GTYPGRKKKK KQTQQIDYSR GSIYHSVEGP
1441: LTGHGESIQD SRTLPFKTHP SQASFVSALG GEDDVIEHLY IVEGEKTVES EQITPQQPVM
1501: NCYQTYLTQF QVINWSVKHP TNKRTSKSSL HRPLDLDTPT SEESSSSFEQ LSVPTFKVIK
1561: QGLTANSLLD RGMQLSGSTS NTPYTPLEKK LADNTDDETL TEEWTLDQPV SQTRTTAIVE
1621: VKGTVDIVLT PLVAEALDRY IEAMVHCAST RHPAAIVDDL HAKVLREAVQ NSKTTFSENL
1681: SSKQDIRGTK TEQSTIGTTN QGQAQTNLTM KQDNVTIKGL QTNVSIPKVN LCLLQASVEE
1741: SPTTAPSRSV THVSLVALCF DRIATQVRMN RGVVEETSNN AEPGRTSNFD RYVHATKMQP
1801: QSSGSLRSNA GAEKGKEIAA KLNIHRVHGQ LRGLDTTDIG TCAITAIPFE KSKVLFTLEE
1861: LDEFTFVDET DQQAVPDVTR IGPSQEKWGW IMFECGLENL TIKGGRQSGA VLYNSFGIMG
1921: KASDTERGGV LTSNNSSDSP TGSGYNTDVS DDNLPCDRTS PSSDLNGNSV SDEQDEGVES
1981: DDLKKDLPLM PPPPDSCSMK LTIKEIWFSF AAPTNVRSHT HAFSRQLNLL STATPAVGAW
2041: LVPIDQLKSS LNKLETEGTL RICAVMGCIM TEALENKSVH FPLRSKYNRL TKVARFLQEN
2101: PSCLLCNILH HYLHQANYSI IDDATMSDGL PALVTLKKGL VALARQWMKF IVVTPAFKGV
2161: SLHRPAQPLK PQIAMDHEHE DGLGLDNGGG LQSDTSADGA EFEFDAATVS EHTMLLEGTA
2221: NRPPPGSSGP VTGAEIMRKL SKTHTHSDSA LKIKGIHPYH SLSYTSGDTA TDSPVHVGRA
2281: GMPVKDSPRK ESLLSYLTGS FPSLHNLLEG TPQRSSAAVK SSSLTRTGNT VATDMLSEHP
2341: LLSEPSSVSF YNWMSNAVGN RGSVLQESPV TKSGHNSLPT GVAPNLPTIP SASDFNTVLS
2401: SDQNTLDGTH SQHSTSQDDV AGVEEANQGF PAVQLADAQV VFKPLLSHTG IQSQDTMPFC
2461: YRMYFGEHLS FSGTLDCLRA DIVDSDTAKE RKGKRARRQG HVNLPPLEFK PALMLGTFSI
2521: SAVVMEKSVC TPQNSTSALS FHDLSKRYYN TFHCNFTISC QSISQHVDMA LVRLIHQFST
2581: MIDDIKATQT DIKLSRYTAG SASPTPTFKT RKHRDFRSSD FSRSSRGSLN GGNRVNNAKN
2641: KRTNNENNKK ESRNKNSLGR SERRTSKVSR KGSKDVVDHM TIHMDDSDSI TVSEQSEPSA
2701: ECWQNMYKLL NFYSLISDPT GILEKSSETF GPAGVRSPTE PTCKVVFENE QDNSSLTKTQ
2761: RKRSLVTSEP QHVTLIVFGI GMVNRTHLEA DIGGLTMESE LKRIHGSFTL KEKMKDVLHQ
2821: KMTETCATAH IGGVNIVLLE GITPNIQLED FPTSPTSTAK QEFLTVVKCS IAKSQALYSA
2881: QRGLKTNNAA VFKVGAISIN IPQHPATLHS MMVRSSHQLS KQISDLIRQP STAPQPVKED
2941: IATPLPSEKT PTSVNQTPVE TNEFPQLPEG LEKKPIVLKF SAMLDGIAIG AALLPSLKAE
3001: YKMGRMRSHG MTGAQTRFTF ELPNHRLRFT SKVSATDMST IPPSASLNLP PVTMSGKYIM
3061: EEHDSYSDQV WSIDELPSKQ GYYLQGNYLR CVAEVGSFEH NLTTDLLNHL VFVQKVFMKE
3121: VNEVIQKVSG GEQPIPLWNE HDGTADGDKP KILLYSLNLQ FKGIQVTATT PSMRAVRFET
3181: GLIELELSNR LQTKASPGSS SYLKLFGKCQ VDLNLALGQI VKHQVYEEAG SDFHQVAYFK
3241: TRIGLRNALR EEISGSSDRE AVLITLNRPI VYAQPVAFDR AVLFWLNYKA AYDNWNEQRM
3301: ALHKDIHMAT KEVVDMLPGI QQTSAQAFGT LFLQLTVNDL GICLPITNTA QSNHTGDLDT
3361: GSALVLTIES TLITACSSES LVSKGHFKNF CIRFADGFET SWDDWKPEIH GDLVMNACVV
3421: PDGTYEVCSR TTGQAAAESS SAGTWTLNVL WKMCGIDVHM DPNIGKRLNA LGNTLTTLTG
3481: EEDIDDIADL NSVNIADLSD EDEVDTMSPT IHTEATDYRR QAASASQPGE LRGRKIMKRI
3541: VDIRELNEQA KVIDDLKKLG ASEGTINQEI QRYQQLESVA VNDIRRDVRK KLRRSSMRAA
3601: SLKDKWGLSY KPSYSRSKSI SASGRPPLKR MERASSRVGE TEELPEIRVD AASPGPRVTF
3661: NIQDTFPEET ELDLLSVTIE GPSHYSSNSE GSCSVFSSPK TPGGFSPGIP FQTEEGRRDD
3721: SLSSTSEDSE KDEKDEDHER ERFYIYRKPS HTSRKKATGF AAVHQLFTER WPTTPVNRSL
3781: SGTATERNID FELDIRVEID SGKCVLHPTT LLQEHDDISL RRSYDRSSRS LDQDSPSKKK
3841: KFQTNYASTT HLMTGKKVPS SLQTKPSDLE TTVFYIPGVD VKLHYNSKTL KTESPNASRG
3901: SSLPRTLSKE SKLYGMKDSA TSPPSPPLPS TVQSKTNTLL PPQPPPIPAA KGKGSGGVKT
3961: AKLYAWVALQ SLPEEMVISP CLLDFLEKAL ETIPITPVER NYTAVSSQDE DMGHFEIPDP
4021: MEESTTSLVS SSTSAYSSFP VDVVVYVRVQ PSQIKFSCLP VSRVECMLKL PSLDLVFSSN
4081: RGELETLGTT YPAETLSPGG NATQSGTKTS ASKTGIPGSS GLGSPLGRSR HSSSQSDLTS
4141: SSSSSSGLSF TACMSDFSLY VFHPYGAGKQ KTAVSGLTPG SGGLGNVDEE PTSVTGRKDS
4201: LSINLEFVKV SLSRIRRSGG ASFFESQSVS KSASKMDTTL INISAVCDIG SASFKYDMRR
4261: LSEILAFPRA WYRRSIARRL FLGDQTINLP TSGPGTPDSI EGVSQHLSPE SSRKAYCKTW
4321: EQPSQSASFT HMPQSPNVFN EHMTNSTMSP GTVGQSLKSP ASIRSRSVSD SSVPRRDSLS
4381: KTSTPFNKSN KAASQQGTPW ETLVVFAINL KQLNVQMNMS NVMGNTTWTT SGLKSQGRLS
4441: VGSNRDREIS MSVGLGRSQL DSKGGVVGGT IDVNALEMVA HISEHPNQQP SHKIQITMGS
4501: TEARVDYMGS SILMGIFSNA DLKLQDEWKV NLYNTLDSSI TDKSEIFVHG DLKWDIFQVM
4561: ISRSTTPDLI KIGMKLQEFF TQQFDTSKRA LSTWGPVPYL PPKTMTSNLE KSSQEQLLDA
4621: AHHRHWPGVL KVVSGCHISL FQIPLPEDGM QFGGSMSLHG NHMTLACFHG PNFRSKSWAL
4681: FHLEEPNIAF WTEAQKIWED GSSDHSTYIV QTLDFHLGHN TMVTKPCGAL ESPMATITKI
4741: TRRRHENPPH GVASVKEWFN YVTATRNEEL NLLRNVDANN TENSTTVKNS SLLSGFRGGS
4801: SYNHETETIF ALPRMQLDFK SIHVQEPQEP SLQDASLKPK VECSVVTEFT DHICVTMDAE
4861: LIMFLHDLVS AYLKEKEKAI FPPRILSTRP GQKSPIIIHD DNSSDKDRED SITYTTVDWR
4921: DFMCNTWHLE PTLRLISWTG RKIDPVGVDY ILQKLGFHHA RTTIPKWLQR GVMDPLDKVL
4981: SVLIKKLGTA LQDEKEKKGK DKEEH