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8.A.88  The Calciquestrin (CAQS) Family 

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein that acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. The protein can bind around 80 Ca2+ ions. It regulates the release of lumenal Ca2+ via the calcium release channel RYR1 which plays an important role in triggering muscle contraction (Sanchez et al. 2012).

This family belongs to the: LysE Superfamily.

References associated with 8.A.88 family:

Guerra, C. and M. Molinari. (2020). Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5. Cells 9:. 32878123
Haugstetter, J., T. Blicher, and L. Ellgaard. (2005). Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. J. Biol. Chem. 280: 8371-8380. 15623505
Ihara, M., S. Furutani, S. Shigetou, S. Shimada, K. Niki, Y. Komori, M. Kamiya, W. Koizumi, L. Magara, M. Hikida, A. Noguchi, D. Okuhara, Y. Yoshinari, S. Kondo, H. Tanimoto, R. Niwa, D.B. Sattelle, and K. Matsuda. (2020). Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Proc. Natl. Acad. Sci. USA 117: 16283-16291. 32611810
Lee, S., Y. Shin, K. Kim, Y. Song, Y. Kim, and S.W. Kang. (2020). Protein Translocation Acquires Substrate Selectivity Through ER Stress-Induced Reassembly of Translocon Auxiliary Components. Cells 9:. 32102453
Sanchez, E.J., K.M. Lewis, B.R. Danna, and C. Kang. (2012). High-capacity Ca2+ binding of human skeletal calsequestrin. J. Biol. Chem. 287: 11592-11601. 22337878