8.A.88.2.6
Thioredoxin-related transmembrane protein 3 (TMX3) of 431 aas and 2 TMSs, N- and C-terminal. It is essential to enable robust expression in Xenopus laevis oocytes of honeybee (Apis mellifera) and bumblebee (Bombus terrestris) as well as fruit fly (Drosophila melanogaster) nAChR heteromers targeted by neonicotinoids and not hitherto robustly expressed. This has enabled the characterization of picomolar target site actions of neonicotinoids, findings important in understanding their toxicity (Ihara et al. 2020).
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| Accession Number: | NP_648847.3 |
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| Protein Name: | NP_648847.3 uncharacterized protein Dmel_CG5027 [Drosophila melanogaster] |
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| Length: | 431 |
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| Molecular Weight: | |
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| Species: | Drosophila melanogaster [7227] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MSPNSMWIFG LISALLLTLG STGLSSKVLE LSDRFIDVRH EGQWLVMFYA PWCGYCKKTE
61: PIFALVAQAL HATNVRVGRL DCTKYPAAAK EFKVRGYPTI MFIKGNMEFT YNGDRGRDEL
121: VDYALRMSGP PVQLVTRTES VDMLKGSHTI FFIFVGQQEG VVWDTYYAAA EGYQEHGFFY
181: ATSEDIAAQH FDFEKLPAVI VYKEEQHHFY PHGHLAHEMD PNEVNETVFQ WVNVERFTLF
241: PKVTRFNIHQ LLKTNKYLVL AVVQEDKLNQ IATHELEFRD MVEGVIRKHR ARYHDKFQFG
301: WIGEPSIAHS IILDQLPTPH LIAINSSTQH HFIPEDDPMQ MTPQALHLFL ESIRNESAIA
361: YGGDTYFVRL NRALFEVRRA LRDMWLGNPV LTTVIFGLPL GFLSLIMYSI FCGDCLVTEE
421: DPDEDHEKKE