8.A.88.2.7
Protein disulfide-isomerase A3, PDIA3, ERP57, ERP60, GRP58, of 505 aas and 1 N-terminal TMS. Protein translocation in the ER via the general secretory pathway (3.A.5) acquires substrate selectivity through ER stress-induced reassembly of translocon auxiliary components including calnexin and ERP57 (Lee et al. 2020).
|
| Accession Number: | P30101 |
|---|
| Protein Name: | Protein disulfide-isomerase A3 |
|---|
| Length: | 505 |
|---|
| Molecular Weight: | 56782.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum1 |
|---|
| Substrate |
protein |
|---|
1: MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV EFFAPWCGHC
61: KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT
121: ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASIVGFF DDSFSEAHSE FLKAASNLRD
181: NYRFAHTNVE SLVNEYDDNG EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI
241: FGICPHMTED NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA
301: VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE RFLQDYFDGN
361: LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE FYAPWCGHCK NLEPKYKELG
421: EKLSKDPNIV IAKMDATAND VPSPYEVRGF PTIYFSPANK KLNPKKYEGG RELSDFISYL
481: QREATNPPVI QEEKPKKKKK AQEDL