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8.B.4.1.14
T-2 (chi -or lambda-)conotoxin MrIA precursor (61aas) (inhibitor of the human norepinephrine transporter) (Lovelace et al., 2006). These toxins have a unique disulfide arrangement and folding pattern, and they contain 4-trans hydroxyproline (Balaji et al. 2000).

Accession Number:P58808
Protein Name:T-2-conotoxin MrIA
Length:61
Molecular Weight:6499.00
Species:Conus marmoreus (Marble cone) [42752]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

Gene Ontology

GO:0005576 C:extracellular region
GO:0009405 P:pathogenesis

References (7)

[1] “Isolation and characterization of a novel conus peptide with apparent antinociceptive activity.”  McIntosh J.M.et.al.   10900201
[2] “Lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus.”  Balaji R.A.et.al.   10988292
[3] “Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.”  Sharpe I.A.et.al.   11528421
[4] “Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship.”  Sharpe I.A.et.al.   12885787
[5] “Chi-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter.”  Bryan-Lluka L.J.et.al.   12837768
[6] “Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain.”  Nielsen C.K.et.al.   16154696
[7] “Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.”  Nilsson K.P.R.et.al.   15931669
Structure:
2EW4   2J15     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRCLPVLIIL LLLTASAPGV VVLPKTEDDV PMSSVYGNGK SILRGILRNG VCCGYKLCHP 
61:	C