| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.B.4.1.1 | Conotoxin, 33 aas | Eukaryota |
Metazoa | Conotoxin of Conus ventricosus (cone snail) (P83301) |
|
8.B.4.1.2 | Conotoxin scaffold VI/VII precursor (CSP), 79 aas | Eukaryota |
Metazoa | CSP of Conus pennaceus (AAG60403) |
|
8.B.4.1.3 | Conopeptide precursor of 82 aas and 1 TMS. | Eukaryota |
Metazoa | Conopeptide precursor of Conus marmoreus (marble cone) |
|
8.B.4.1.4 | O-superfamily conotoxin of 73 aas | Eukaryota |
Metazoa | Conus toxin of Conus ebraeus |
|
8.B.4.1.5 | Huwentoxin-X or Ω-theraphotoxin-Hh1a of 68 aas. Voltage-gated Ca2+ channel blocker. The 3-d solution structure is known (Liu et al. 2006). | Eukaryota |
Metazoa | Hwentoxin-X of Haplopelma schmidti (Selenocosmia huwena) |
|
8.B.4.1.6 | U4-therophotoxin-Cj1a of 74 aas | Eukaryota |
Metazoa | Therophotoxin of Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao) |
|
8.B.4.1.7 | δ-conotoxin, TxVIA of 78 aas and 1 TMS. Binds to the extracellular sides of voltage-gated sodium
channels (Nav) and inhibits the inactivation process. Binding of this
toxin is calcium-dependent but not voltage-dependent. It is important in mollusks for the paralysis of prey. The 3-d solution structure is known (Kohno et al. 2002). | Eukaryota |
Metazoa | Conotoxin of Conus textile (Cloth-of-gold cone) |
|
8.B.4.1.8 | Epsilon-conotoxin, TxVA, of 67 aas. ε-Conotoxins act at presynaptic membranes, blocking calcium channels or G protein-coupled receptors. They causes hyperactivity upon intracranial injection into mice and dorsal fins drooping in fish. | Eukaryota |
Metazoa | ε-Conotoxin of Conus textile (Cloth-of-gold cone) |
|
8.B.4.1.9 | Mu (μ)-conotoxin GVIIJ of 82 aas and 1 TMS. Mu-conotoxins block voltage-gated sodium channels
(Nav). This toxin (GVIIJ (SSG)) blocks Nav1.1/SCN1A (Kd=11 nM),
Nav1.2/SCN2A (Kd=11 nM), Nav1.3/SCN3A (Kd=15 nM), Nav1.4/SCN4A (Kd=4.7
nM), Nav1.6/SCN8A (Kd=360 nM) and Nav1.7/SCN9A (Kd=41 nM) (Gajewiak et al. 2014; Zhang et al. 2015). Coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) protects rNav1.1-1.7 against block by the toxin (Wilson et al. 2015). | Eukaryota |
Metazoa | Mu-conotoxin GVIIJ of Conus geographus (Geography cone) (Nubecula geographus) |
|
8.B.4.1.10 | Conotoxin of 80 aas and 1 TMS. | Eukaryota |
Opisthokonta | Cx of Conus praecellens |
|
8.B.4.2.1 | T-2 (chi -or lambda-)conotoxin MrIA precursor (61aas) (inhibitor of the human norepinephrine transporter) (Lovelace et al., 2006). These toxins have a unique disulfide arrangement and folding pattern, and they contain 4-trans hydroxyproline (Balaji et al. 2000). | Eukaryota |
Metazoa | Conotoxin MrIA of Conus marmoreus (P58808) |
|
8.B.4.3.1 | Conotoxin Ca5.1 precursor (71 aas) (Peng et al., 2007) | Eukaryota |
Metazoa | Conotoxin Ca5.1 precursor of Conus caracteristicus (P0C666) |