TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.B.4.1.1









Conotoxin, 33 aas
Eukaryota
Metazoa
Conotoxin of Conus ventricosus (cone snail) (P83301)
8.B.4.1.2









Conotoxin scaffold VI/VII precursor (CSP), 79 aas
Eukaryota
Metazoa
CSP of Conus pennaceus (AAG60403)
8.B.4.1.3









Conopeptide precursor of 82 aas and 1 TMS.

Eukaryota
Metazoa
Conopeptide precursor of Conus marmoreus (marble cone)
8.B.4.1.4









O-superfamily conotoxin of 73 aas

Eukaryota
Metazoa
Conus toxin of Conus ebraeus
8.B.4.1.5









Huwentoxin-X or Ω-theraphotoxin-Hh1a of 68 aas.  Voltage-gated Ca2+ channel blocker.  The 3-d solution structure is known (Liu et al. 2006).

Eukaryota
Metazoa
Hwentoxin-X of Haplopelma schmidti (Selenocosmia huwena)
8.B.4.1.6









U4-therophotoxin-Cj1a of 74 aas

Eukaryota
Metazoa
Therophotoxin of Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
8.B.4.1.7









δ-conotoxin, TxVIA of 78 aas and 1 TMS.  Binds to the extracellular sides of voltage-gated sodium channels (Nav) and inhibits the inactivation process. Binding of this toxin is calcium-dependent but not voltage-dependent.  It is important in mollusks for the paralysis of prey.  The 3-d solution structure is known (Kohno et al. 2002).

Eukaryota
Metazoa
Conotoxin of Conus textile (Cloth-of-gold cone)
8.B.4.1.8









Epsilon-conotoxin, TxVA, of 67 aas.  ε-Conotoxins act at presynaptic membranes, blocking calcium channels or G protein-coupled receptors. They causes hyperactivity upon intracranial injection into mice and dorsal fins drooping in fish.

Eukaryota
Metazoa
ε-Conotoxin of Conus textile (Cloth-of-gold cone)
8.B.4.1.9









Mu (μ)-conotoxin GVIIJ of 82 aas and 1 TMS.  Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin (GVIIJ (SSG)) blocks Nav1.1/SCN1A (Kd=11 nM), Nav1.2/SCN2A (Kd=11 nM), Nav1.3/SCN3A (Kd=15 nM), Nav1.4/SCN4A (Kd=4.7 nM), Nav1.6/SCN8A (Kd=360 nM) and Nav1.7/SCN9A (Kd=41 nM) (Gajewiak et al. 2014; Zhang et al. 2015). Coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) protects rNav1.1-1.7 against block by the toxin (Wilson et al. 2015).

Eukaryota
Metazoa
Mu-conotoxin GVIIJ of Conus geographus (Geography cone) (Nubecula geographus)
8.B.4.1.10









Conotoxin of 80 aas and 1 TMS.

Eukaryota
Opisthokonta
Cx of Conus praecellens
8.B.4.2.1









T-2 (chi -or lambda-)conotoxin MrIA precursor (61aas) (inhibitor of the human norepinephrine transporter) (Lovelace et al., 2006). These toxins have a unique disulfide arrangement and folding pattern, and they contain 4-trans hydroxyproline (Balaji et al. 2000).

Eukaryota
Metazoa
Conotoxin MrIA of Conus marmoreus (P58808)
8.B.4.3.1









Conotoxin Ca5.1 precursor (71 aas) (Peng et al., 2007)

Eukaryota
Metazoa
Conotoxin Ca5.1 precursor of Conus caracteristicus (P0C666)