8.C.11.  The MS-L6 OxPhos Inhibitor (MS-L6) Family 

MS-L6 induces cell death in a variety of cancer cell lines, including B-cell and T-cell lymphomas as well as pediatric sarcoma. It is a potent inhibitor of oxidative phosphorylation (OXPHOS) that can acts as electron transport chain complexes I (ETC-I) combining inhibition of NADH oxidation and an uncoupling effect. Assuming that the latter effect is due to facilitating H+ fluxes across the inner mitochondrial membrane, it must also be an ionophore.  This novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity (Al Assi et al. 2024).

inhibitor of oxidative phosphorylation