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9.A.14.1.1 Long wave-sensitive opsin (red cone photoreceptor pigment). Phosphorylated on Thr and Ser in the C-terminal region. Defects cause color blindness (protanopia). Catalyzes phospholipid flipping (Menon et al., 2011).
Accession Number:	P04000
Protein Name:	Long-wave-sensitive opsin 1
Length:	364
Molecular Weight:	40572.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	phospholipid

Entrez Gene ID:	5956
Pfam:	PF00001
KEGG:	hsa:5956
Gene Ontology GO:0005887 C:integral to plasma membrane GO:0004930 F:G-protein coupled receptor activity GO:0009881 F:photoreceptor activity GO:0007602 P:phototransduction GO:0018298 P:protein-chromophore linkage GO:0007601 P:visual perception
References (7) [1] “Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.” Nathans J.et.al. 2937147 [2] “The DNA sequence of the human X chromosome.” Ross M.T.et.al. 15772651 [3] “Molecular biology of the visual pigments.” Applebury M.L.et.al. 3303660 [4] “Polymorphism in red photopigment underlies variation in colour matching.” Winderickx J.et.al. 1557123 [5] “Genetic heterogeneity among blue-cone monochromats.” Nathans J.et.al. 8213841 [6] “Gene conversion between red and defective green opsin gene in blue cone monochromacy.” Reyniers E.et.al. 8666378 [7] “Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.” Ueyama H.et.al. 12051694

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR WVYHLTSVWM 
61:	IFVVTASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL AETVIASTIS IVNQVSGYFV 
121:	LGHPMCVLEG YTVSLCGITG LWSLAIISWE RWLVVCKPFG NVRFDAKLAI VGIAFSWIWS 
181:	AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMVTCCII PLAIIMLCYL 
241:	QVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMIFAYCVC WGPYTFFACF AAANPGYAFH 
301:	PLMAALPAYF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA SKTEVSSVSS 
361:	VSPA

9.A.14.1.1
Long wave-sensitive opsin (red cone photoreceptor pigment). Phosphorylated on Thr and Ser in the C-terminal region. Defects cause color blindness (protanopia). Catalyzes phospholipid flipping (Menon et al., 2011).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

9.A.14.1.1Long wave-sensitive opsin (red cone photoreceptor pigment). Phosphorylated on Thr and Ser in the C-terminal region. Defects cause color blindness (protanopia). Catalyzes phospholipid flipping (Menon et al., 2011).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

9.A.14.1.1
Long wave-sensitive opsin (red cone photoreceptor pigment). Phosphorylated on Thr and Ser in the C-terminal region. Defects cause color blindness (protanopia). Catalyzes phospholipid flipping (Menon et al., 2011).