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9.A.14.1.1
Long wave-sensitive opsin (red cone photoreceptor pigment). Phosphorylated on Thr and Ser in the C-terminal region. Defects cause color blindness (protanopia). Catalyzes phospholipid flipping (Menon et al., 2011).

Accession Number:P04000
Protein Name:Long-wave-sensitive opsin 1
Length:364
Molecular Weight:40572.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate phospholipid

Cross database links:

Entrez Gene ID: 5956   
Pfam: PF00001   
KEGG: hsa:5956   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004930 F:G-protein coupled receptor activity
GO:0009881 F:photoreceptor activity
GO:0007602 P:phototransduction
GO:0018298 P:protein-chromophore linkage
GO:0007601 P:visual perception

References (7)

[1] “Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.”  Nathans J.et.al.   2937147
[2] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[3] “Molecular biology of the visual pigments.”  Applebury M.L.et.al.   3303660
[4] “Polymorphism in red photopigment underlies variation in colour matching.”  Winderickx J.et.al.   1557123
[5] “Genetic heterogeneity among blue-cone monochromats.”  Nathans J.et.al.   8213841
[6] “Gene conversion between red and defective green opsin gene in blue cone monochromacy.”  Reyniers E.et.al.   8666378
[7] “Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.”  Ueyama H.et.al.   12051694

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR WVYHLTSVWM 
61:	IFVVTASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL AETVIASTIS IVNQVSGYFV 
121:	LGHPMCVLEG YTVSLCGITG LWSLAIISWE RWLVVCKPFG NVRFDAKLAI VGIAFSWIWS 
181:	AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMVTCCII PLAIIMLCYL 
241:	QVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMIFAYCVC WGPYTFFACF AAANPGYAFH 
301:	PLMAALPAYF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA SKTEVSSVSS 
361:	VSPA