9.A.14.1.11 G-protein coupled receptor 161, Gpr161 of 529 aas. Key negative regulator of Shh signaling and the sonic hedgehog pathway via cAMP signaling. Shh signalling promotes the processing of GLI3 into GLI3R during neural tube development (Mukhopadhyay et al. 2013).
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Accession Number: | Q8N6U8 |
Protein Name: | G-protein coupled receptor 161 |
Length: | 529 |
Molecular Weight: | 58559.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Cell projection1 / Multi-pass membrane protein2 |
Substrate |
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1: MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV TLYKKSYLLT
61: LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC NFSALLYLLI SSASMLTLGV
121: IAIDRYYAVL YPMVYPMKIT GNRAVMALVY IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA
181: AWHREPGYTA FWQIWCALFP FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK
241: NSSTSTSSSG SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS
301: VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV QRQRTSRLFS
361: ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD SGTDMMLLED YTSDDNPPSH
421: CTCPPKRRSS VTFEDEVEQI KEAAKNSILH VKAEVHKSLD SYAASLAKAI EAEAKINLFG
481: EEALPGVLVT ARTVPGGGFG GRRGSRTLVS QRLQLQSIEE GDVLAAEQR