9.A.14.1.17
Bovine rhodopsin of 348 aas and 7 TMSs. It is the photoreceptor required for image-forming
vision at low light intensity. Also required for photoreceptor cell viability
after birth. Light-induced isomerization of 11-cis to
all-trans retinal triggers a conformational change that activates
signaling via G-proteins (Singhal et al. 2016; Deupi et al. 2012). The x-ray structure has been determined at high resolution, and the folding and oligomerization (Okada and Palczewski 2001; Brown and Ernst 2017). This protein is 93% identical to the human ortholog (TC# 9.A.14.1.2).
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| Accession Number: | P02699 |
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| Protein Name: | Rhodopsin |
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| Length: | 348 |
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| Molecular Weight: | 39008.00 |
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| Species: | Bos taurus (Bovine) [9913] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
phospholipid, proton |
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1: MNGTEGPNFY VPFSNKTGVV RSPFEAPQYY LAEPWQFSML AAYMFLLIML GFPINFLTLY
61: VTVQHKKLRT PLNYILLNLA VADLFMVFGG FTTTLYTSLH GYFVFGPTGC NLEGFFATLG
121: GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLVGWSRYIP
181: EGMQCSCGID YYTPHEETNN ESFVIYMFVV HFIIPLIVIF FCYGQLVFTV KEAAAQQQES
241: ATTQKAEKEV TRMVIIMVIA FLICWLPYAG VAFYIFTHQG SDFGPIFMTI PAFFAKTSAV
301: YNPVIYIMMN KQFRNCMVTT LCCGKNPLGD DEASTTVSKT ETSQVAPA