9.A.14.1.20
Neurotensin receptor-2, NTR2 or NTR3, of 410 aas and 7 TMSs. Sortilin/NTSR3 (membrane-bound and soluble (extracellular) forms) are involved in many pathophysiological processes from cancer development to cardiovascular diseases, Alzheimer's disease, diabetes, and major depression (Mazella 2022).
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| Accession Number: | O95665 |
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| Protein Name: | Neurotensin receptor type 2 |
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| Length: | 410 |
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| Molecular Weight: | 45385.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN ALSAHVVLKA
61: RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP WVFGDLGCRG YYFVHELCAY
121: ATVLSVAGLS AERCLAVCQP LRARSLLTPR RTRWLVALSW AASLGLALPM AVIMGQKHEL
181: ETADGEPEPA SRVCTVLVSR TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV
241: PSTSTPGSST PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
301: AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS SAVTPLLYNA
361: VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS GFGDPPETRT