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9.A.14.1.3
Melatonin receptor type 1A, or MT1 of 350 aas and 7 TMSs.  Although the MT1 and 5-HT receptors have similar endogenous ligands, and agomelatine acts on both receptors, the receptors differ markedly in the structure and composition of their ligand pockets; in MT1, access to the ligand pocket is tightly sealed from solvent by extracellular loop 2, leaving only a narrow channel between transmembrane helices IV and V that connects it to the lipid bilayer (Stauch et al. 2019). The binding site is extremely compact, and ligands interact with MT1 mainly by strong aromatic stacking with Phe179 and auxiliary hydrogen bonds with Asn162 and Gln181. Free-energy simulations support a lipophilic binding route for melatonin receptors (Elisi et al. 2021).

Accession Number:P48039
Protein Name:Melatonin receptor type 1A
Length:350
Molecular Weight:39375.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 4543   
Pfam: PF00001   
KEGG: hsa:4543   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0008502 F:melatonin receptor activity
GO:0007623 P:circadian rhythm
GO:0007187 P:G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0007617 P:mating behavior

References (3)

[1] “Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.”  Reppert S.M.et.al.   7946354
[2] “Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.”  Ebisawa T.et.al.   10471411
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
Structure:
6ME2   6ME3   6ME4   6ME5   6PS8     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN 
61:	AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG 
121:	IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA 
181:	QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM 
241:	FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ 
301:	NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV